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Displaying results 5181 - 5190 of 10000 in total
  1. Drug

    Efonidipine

    go.drugbank.com/drugs/DB09235
    Investigational

    It has also been studied in atherosclerosis and acute renal failure [A32001]. This drug is also known as NZ-105, and several studies have been done on its pharmacokinetics in animals [L1456]. … Efonidipine is a calcium channel blocker of the _dihydropyridine class_, commercialized by Shionogi & Co. (Japan). Initially, it was marketed in 1995 under the trade name, _Landel_.

    Categories: Calcium-Regulating Hormones and Agents
  2. Indication

    Fissure;Anal

    go.drugbank.com/conditions/DBCOND0080687
    Drugs: Bismuth subgallate · Bufexamac · Carvasept · Diltiazem · Esculin · Fluocinolone acetonide +8 more
    Synonyms: Fissure in ano, Fissure-in-ano
  3. Drug

    1D09C3

    go.drugbank.com/drugs/DB05121
    Experimental

    The antibody was isolated in collaboration with MorphoSys from its HuCAL(R) library of human antibodies. 1D09C3 binds to certain cell surface receptors, selectively killing activated, proliferating MHC … class II-positive tumor cells, which include those in B-cell and T-cell lymphomas. 1D09C3 has been shown to induce programmed cell death and does not require a functioning immune system for its cell-killing

  4. Drug

    Tipifarnib

    go.drugbank.com/drugs/DB04960
    Investigational

    Tipifarnib (R-115777) is a substance that is being studied in the treatment of acute myeloid leukemia (AML) and other types of cancer.

  5. Drug

    Tocainide

    go.drugbank.com/drugs/DB01056
    ApprovedWithdrawn

    An antiarrhythmic agent which exerts a potential- and frequency-dependent block of sodium channels.

  6. Drug

    Cyclic GMP

    go.drugbank.com/drugs/DB02315
    Experimental

    Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed) … It is a cellular regulatory agent and has been described as a second messenger.

    Categories: Nucleic Acids, Nucleotides, and Nucleosides
  7. Drug

    Depulfavirine

    go.drugbank.com/drugs/DB18890
    Investigational

    Depulfavirine is under investigation in clinical trial NCT05204394 (Study to Evaluate Efficacy and Safety of Switching to VM-1500A-LAI + 2nrtis From the 1st Line Standard of Care Therapy).

  8. Drug

    Elacytarabine

    go.drugbank.com/drugs/DB05494
    Investigational

    melanoma and ovarian cancer. … Elacytarabine is a fatty acid derivative of [cytarabine], an approved cytotoxic cancer drug. Cytarabine has limitations such as minimal uptake in solid tumours and is only used to treat leukaemia.

    Categories: Nucleic Acids, Nucleotides, and Nucleosides
  9. Drug

    Pentamidine

    go.drugbank.com/drugs/DB00738
    ApprovedInvestigational

    It may cause diabetes mellitus, central nervous system damage, and other toxic effects. … Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients.

    Categories: Agents Against Leishmaniasis and Trypanosomiasis, Antiparasitic Products, Insecticides and Repellents
  10. Drug

    Methyl undecenoyl leucinate

    go.drugbank.com/drugs/DB11272
    Approved

    It is an α-MSH antagonist that inhibits melanin synthesis and tyrosinase activity and reduces expression of various melanogenic genes. … Methyl undecenoyl leucinate is an active ingredient in whitening creams.