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Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
go.drugbank.com/bio_entities/BE0009517TargetHumansParticipates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:26774281, PubMed:9038203). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion ...
Polypeptides: Phosphatidylinositol 5-phosphate 4-kinase type-2 betaSynonyms: Diphosphoinositide kinase 2-beta, PtdIns(5)P-4-kinase isoform 2-betaPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma
go.drugbank.com/bio_entities/BE0009518TargetHumansPhosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-ind...
Polypeptides: Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaLeukocyte immunoglobulin-like receptor subfamily B member 2
go.drugbank.com/bio_entities/BE0010561TargetHumansRecognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells
Polypeptides: Leukocyte immunoglobulin-like receptor subfamily B member 2Synonyms: LIR-2, Leukocyte immunoglobulin-like receptor 2ATP-binding cassette sub-family C member 2
go.drugbank.com/bio_entities/BE0001069TargetTransporterHumansATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. Operates at apical membranes of polarized cells such as ...
Polypeptides: ATP-binding cassette sub-family C member 2Synonyms: Multidrug resistance-associated protein 22-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
go.drugbank.com/bio_entities/BE0001303TargetShigella flexneriCatalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate
Polypeptides: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseFunction: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity4-hydroxy-3-methylbut-2-enyl diphosphate reductase
go.drugbank.com/bio_entities/BE0004045TargetEscherichia coli (strain K12)Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).
Polypeptides: 4-hydroxy-3-methylbut-2-enyl diphosphate reductaseSynonyms: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
go.drugbank.com/bio_entities/BE0004091TargetShewanella oneidensis (strain MR-1)Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate
Polypeptides: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseFunction: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
go.drugbank.com/bio_entities/BE0004142TargetMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate
Polypeptides: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseFunction: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activityAlpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
go.drugbank.com/bio_entities/BE0004519TargetHumansInitiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans
Polypeptides: Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferasePotassium voltage-gated channel subfamily B member 2
go.drugbank.com/bio_entities/BE0004722TargetHumansVoltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, let...
Polypeptides: Potassium voltage-gated channel subfamily B member 2