ATP-binding cassette sub-family C member 2

BE0001069ProteinHumansABCC2

ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. It is acted on by 111 drugs in DrugBank.

Gene name
ABCC2
UniProtKB entry
Q92887Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
1,545 residues · 174,206 Da
Also known as
7.6.2.- · 7.6.2.2 · 7.6.2.3 · Canalicular multidrug resistance protein · Canalicular multispecific organic anion transporter 1

Resolves to

Protein
UniProtQ92887UniProt nameMRP2_HUMAN
Gene
HGNCHGNC:53NCBI Gene1244GenBank1764162GeneCardsABCC2
Pharmacology
IUPHAR/GtoPdb780KEGGhsa:1244
Structure
PDB8IZQPDB8IZRPDB8JX7
Drugs

What you can answer from here — as of September 03, 2024

111DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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22GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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260+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-binding cassette sub-family C member 2, how selective are they, and which programs against it are still in active trials?

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