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Displaying results 5361 - 5370 of 10000 in total
  1. Target

    Dual specificity mitogen-activated protein kinase kinase 2

    go.drugbank.com/bio_entities/BE0004744
    TargetHumans

    Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner;...

    Polypeptides: Dual specificity mitogen-activated protein kinase kinase 2Synonyms: MEK 2, MAPKK 2
  2. Target

    Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

    go.drugbank.com/bio_entities/BE0009517
    TargetHumans

    Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:26774281, PubMed:9038203). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion ...

    Polypeptides: Phosphatidylinositol 5-phosphate 4-kinase type-2 betaSynonyms: Diphosphoinositide kinase 2-beta, PtdIns(5)P-4-kinase isoform 2-beta
  3. Target

    Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

    go.drugbank.com/bio_entities/BE0009518
    TargetHumans

    Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-ind...

    Polypeptides: Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
  4. Target

    Leukocyte immunoglobulin-like receptor subfamily B member 2

    go.drugbank.com/bio_entities/BE0010561
    TargetHumans

    Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells

    Polypeptides: Leukocyte immunoglobulin-like receptor subfamily B member 2Synonyms: LIR-2, Leukocyte immunoglobulin-like receptor 2
  5. Drug

    Mercaptopurine

    go.drugbank.com/drugs/DB01033
    ApprovedInvestigational

    An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission...

    Categories: Heterocyclic Compounds, 2-Ring, OAT3/SLC22A8 Substrates with a Narrow Therapeutic IndexSynonyms: 6 MP, 6-MP
  6. Target

    ATP-binding cassette sub-family C member 2

    go.drugbank.com/bio_entities/BE0001069
    TargetTransporterHumans

    ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. Operates at apical membranes of polarized cells such as ...

    Polypeptides: ATP-binding cassette sub-family C member 2Synonyms: Multidrug resistance-associated protein 2
  7. Target

    2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

    go.drugbank.com/bio_entities/BE0001303
    TargetShigella flexneri

    Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate

    Polypeptides: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseFunction: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
  8. Target

    4-hydroxy-3-methylbut-2-enyl diphosphate reductase

    go.drugbank.com/bio_entities/BE0004045
    TargetEscherichia coli (strain K12)

    Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).

    Polypeptides: 4-hydroxy-3-methylbut-2-enyl diphosphate reductaseSynonyms: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase
  9. Target

    2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

    go.drugbank.com/bio_entities/BE0004091
    TargetShewanella oneidensis (strain MR-1)

    Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate

    Polypeptides: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseFunction: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
  10. Target

    2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

    go.drugbank.com/bio_entities/BE0004142
    TargetMycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

    Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate

    Polypeptides: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseFunction: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity