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cGMP-dependent 3',5'-cyclic phosphodiesterase
go.drugbank.com/bio_entities/BE0002085TargetHumanscGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15938621, PubMed:29392776, PubMed:9210593). Ha...
Polypeptides: cGMP-dependent 3',5'-cyclic phosphodiesteraseFunction: 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activitytRNA (cytosine(38)-C(5))-methyltransferase
go.drugbank.com/bio_entities/BE0002517TargetHumansSpecifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) (PubMed:16424344). Has higher activity on tRNA(Asp) modified with queuosine at position 34 (PubMed:30093495)
Polypeptides: tRNA (cytosine(38)-C(5))-methyltransferaseSynonyms: DNA (cytosine-5)-methyltransferase-like protein 2Trafficking protein particle complex subunit 5
go.drugbank.com/bio_entities/BE0004277TargetHumansMay play a role in vesicular transport from endoplasmic reticulum to Golgi
Polypeptides: Trafficking protein particle complex subunit 5Pyridoxal 5'-phosphate synthase subunit Pdx1
go.drugbank.com/bio_entities/BE0009271TargetPlasmodium falciparum (isolate 3D7)Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by Pdx2. … Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
Polypeptides: Pyridoxal 5'-phosphate synthase subunit Pdx1G protein-coupled receptor kinase 5
go.drugbank.com/bio_entities/BE0013072TargetHumansIn addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1.
Polypeptides: G protein-coupled receptor kinase 5Short transient receptor potential channel 5
go.drugbank.com/bio_entities/BE0021113TargetHumansForms a receptor-activated non-selective calcium permeant cation channel (PubMed:16284075, PubMed:38959890, PubMed:37137991). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with...
Polypeptides: Short transient receptor potential channel 5Synonyms: hTRP-5, TRP-55-aminolevulinate synthase, non-specific, mitochondrial
go.drugbank.com/bio_entities/BE0000409TargetHumansCatalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products
Polypeptides: 5-aminolevulinate synthase, non-specific, mitochondrialSynonyms: 5-aminolevulinic acid synthase 1, Delta-ALA synthase 1C-C chemokine receptor type 5
go.drugbank.com/bio_entities/BE0000911TargetHumansReceptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.
Polypeptides: C-C chemokine receptor type 5Synonyms: HIV-1 fusion coreceptor, CCR-55-phosphohydroxy-L-lysine phospho-lyase
go.drugbank.com/bio_entities/BE0002164TargetHumansCatalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde
Polypeptides: 5-phosphohydroxy-L-lysine phospho-lyaseNeuronal acetylcholine receptor subunit alpha-5
go.drugbank.com/bio_entities/BE0003586TargetHumansComponent of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collecti...
Polypeptides: Neuronal acetylcholine receptor subunit alpha-5