Search
Vismodegib
go.drugbank.com/drugs/DB08828ApprovedInvestigational[A258613,A258618,L45803] It was discovered by high-throughput screening of a library of small-molecule compounds and subsequent optimization through medicinal chemistry. … In July 2013, it was approved by the EMA, and since then, it has been approved by several other countries.[A7370,A258618,L45803]
Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substratesSynonyms: 2-chloro-N-(4-chloro-3-pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide, Benzamide, 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)-Prednicarbate
go.drugbank.com/drugs/DB01130ApprovedIt has a favorable benefit-risk ratio, with an inflammatory action similar to that of a medium potency corticosteroid, but with a low potential to cause skin atrophy. … IL-1a is also found in fibroblasts, where it is responsible for proliferation, collagenase induction and IL-6 synthesis, which are related to skin thickness.
Mixtures: SKINPRED® ULTRACategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersDisulfiram
go.drugbank.com/drugs/DB00822ApprovedInvestigationalA carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. … It acts by inhibiting aldehyde dehydrogenase.
Synonyms: N,N,N',N'-tetraethylthiuram disulfide, 1,1'-dithiobis(N,N-diethylthioformamide)Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesRegorafenib
go.drugbank.com/drugs/DB08896ApprovedInvestigationalIt is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. … Regorafenib is an orally-administered inhibitor of multiple kinases.
Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: STIVARGA 40 MG TABLETA RECUBIERTA, STIVARGA 40 MG FILM KAPLI TABLET ,84 ADETCalcium Phosphate
go.drugbank.com/drugs/DB11348ApprovedInvestigationalCalcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes [FDA Label] [L851].
Mixtures: MULTIVIT M® CAPSULAS, Multivitamines Et MinerauxCategories: Compounds used in a research, industrial, or household setting, ascorbic acid (vit C) and calciumBenperidol
go.drugbank.com/drugs/DB12867ApprovedWithdrawnBenperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.
Products: BENPERIDOL-NEURAX 2 MG, BENPERIDOL-NEURAX 4 MGMedazepam
go.drugbank.com/drugs/DB13437InvestigationalMixtures: TRANKO-BUSKAS 10 MG + 10 MG KAPLI TABLET, 40 ADET, TRANKO-BUSKAS 10 MG + 10 MG KAPLI TABLET, 20 ADETCategories: Heterocyclic Compounds, 2-RingReboxetine
go.drugbank.com/drugs/DB00234ApprovedInvestigationalWithdrawnReboxetine has two chiral centers, but it only exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine. … Reboxetine is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD.
Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein inhibitorsProducts: Edronax 4 mg - Tabletten, EDRONAX 4 MG TABLET, 60 ADETLenvatinib
go.drugbank.com/drugs/DB09078ApprovedInvestigationalMost patients with thyroid cancer have a very good prognosis with treatment (98% 5 year survival rate) involving surgery and hormone therapy. … factor (FGF) receptors FGFR1, 2, 3, and 4; the platelet derived growth factor receptor alpha (PDGFRα), KIT, and RET.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamideEncorafenib
go.drugbank.com/drugs/DB11718ApprovedInvestigationalEncorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. … melanoma with a BRAF V600E or V600K mutation, as detected by an FDA-approved test.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: BRAFTOVI® 75 MG CÁPSULAS, BRAFTOVİ 75 MG SERT KAPSÜL, 42 ADET