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Displaying results 541 - 550 of 10000 in total
  1. Target

    Glutathione S-transferase

    go.drugbank.com/bio_entities/BE0002659
    TargetEnzymePlasmodium falciparum

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May also function as a storage protein or ligandin for parasitotoxic ferriprotoporphyrin IX (hemin).

    Polypeptides: Glutathione S-transferase
  2. Drug

    Esmolol

    go.drugbank.com/drugs/DB00187
    ApprovedInvestigationalWithdrawn

    Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker. … It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended therapeutic doses.

    Synonyms: Methyl 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoate, 3-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-propionic acid methyl esterCategories: Cytochrome P-450 Substrates, Adrenergic beta-1 Receptor Antagonists
  3. Drug

    Acazicolcept

    go.drugbank.com/drugs/DB18410
    Investigational

    Synonyms: (133-363) VARIANT (C137>S, L151>A, L152>E, G154>A,, .1-CHAIN C REGION VARIANT C-TERMINAL FRAGMENT), DIMER
  4. Drug

    JNJ-55308942

    go.drugbank.com/drugs/DB19110
    Investigational

    JNJ-55308942 is under investigation in clinical trial NCT05328297 (A Study of JNJ-55308942 in the Treatment of Bipolar Depression).

    Synonyms: (S)-(3-Fluoro-2-(trifluoromethyl)pyridin-4-yl)(1-(5-fluoropyrimidin-2-yl)-6-methyl-6,7-dihydro-1H-[1,2,3]triazolo[4,5-c]pyridin-5(4H)-yl)methanone, ((6S)-1-(5-FLUORO-2-PYRIMIDINYL)-1,4,6,7-TETRAHYDRO-6-METHYL-5H-1,2,3-TRIAZOLO(4,5-C)PYRIDIN-5-YL)(3-FLUORO-2-(TRIFLUOROMETHYL)-4-PYRIDINYL)METHANONECategories: Heterocyclic Compounds, 1-Ring
  5. Target

    Glutathione S-transferase A4

    go.drugbank.com/bio_entities/BE0000811
    TargetHumans

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE)

    Polypeptides: Glutathione S-transferase A4Synonyms: Glutathione S-transferase A4-4
  6. Target

    (S)-2-haloacid dehalogenase

    go.drugbank.com/bio_entities/BE0001613
    TargetXanthobacter autotrophicus

    Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids (PubMed:1744048). … Active with 2-halogenated carboxylic acids and converts only the S-isomer (or L-isomer) of 2-chloropropionic acid with inversion of configuration to produce R-lactate (or D-isomer) (PubMed:1744048).

    Polypeptides: (S)-2-haloacid dehalogenaseFunction: (S)-2-haloacid dehalogenase activity
  7. Target

    Glutathione S-transferase A3

    go.drugbank.com/bio_entities/BE0000809
    TargetEnzymeHumans

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-...

    Polypeptides: Glutathione S-transferase A3Synonyms: Glutathione S-transferase A3-3
  8. Target

    Glutathione S-transferase A5

    go.drugbank.com/bio_entities/BE0000813
    TargetHumans

    Polypeptides: Glutathione S-transferase A5Synonyms: Glutathione S-transferase A5-5
  9. Target

    Glutathione S-transferase P

    go.drugbank.com/bio_entities/BE0000814
    TargetEnzymeHumans

    Catalyzes conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:1540159, PubMed:1567427, PubMed:8433974). Involved in the formation of glutathione conjugates of both prostagland...

    Polypeptides: Glutathione S-transferase P
  10. Target

    Glutathione S-transferase A2

    go.drugbank.com/bio_entities/BE0002189
    TargetEnzymeHumans

    Catalyzes the conjugation of glutathione to a large variety of electrophilic compounds

    Polypeptides: Glutathione S-transferase A2