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Displaying results 541 - 550 of 10000 in total
  1. Target

    Interleukin-10

    go.drugbank.com/bio_entities/BE0002484
    TargetHumans

    -1 alpha, IL-1 beta, IL-6, IL-8 and TNF (PubMed:11564774, PubMed:1940799, PubMed:7512027). … as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL

    Synonyms: IL-10
  2. Drug

    Nizatidine

    go.drugbank.com/drugs/DB00585
    Approved

    The drug is used for the treatment of duodenal ulcers.

    Synonyms: N-(4-(6-Methylamino-7-nitro-2-thia-5-aza-6-hepten-1-yl)-2-thiazolylmethyl)-N,N-dimethylamineProducts: AXID 25 MG/ML IV IMF. ICIN ENJ. AMPUL, 5 ADET, AXID INYECTABLE 100 MG/4 ML
  3. Target

    Interleukin-1 alpha

    go.drugbank.com/bio_entities/BE0004734
    TargetHumans

    Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems (PubMed:26439902). After binding to its recepto...

    Synonyms: IL-1 alpha
  4. Drug

    Coenzyme M

    go.drugbank.com/drugs/DB09110
    ApprovedInvestigational

    Coenzyme M (commonly known by its salt form, Mesna) is a synthetic sulfhydryl (thiol) compound and is used for prophylaxis of Ifosfamide and cyclophosphamide induced hemorrhagic cystitis.[A18572]

    Categories: Compounds used in a research, industrial, or household settingProducts: UROMITEXAN 400 MG/4 ML IV ENJEKSİYONLUK ÇÖZELTİ İÇEREN AMPUL, 15 ADET, MESNA 100 MG/ML
  5. Drug

    Acetazolamide

    go.drugbank.com/drugs/DB00819
    ApprovedInvestigationalVet approved

    It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual … One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures.

    Synonyms: N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide, N-[5-(aminosulfonyl)-1,3,5-thiadiazol-2-yl]acetamideProducts: Diamox IV 500mg
  6. Target

    Interleukin-2

    go.drugbank.com/bio_entities/BE0001029
    TargetHumans

    Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG) (PubMed:16293754, PubMed:16477002 … Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3 (PubMed:7973659).

    Synonyms: IL-2
  7. Target

    Interleukin-22 receptor subunit alpha-1

    go.drugbank.com/bio_entities/BE0016650
    TargetHumans

    Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of ...

    Synonyms: IL-22RA1, IL-22R-alpha-1
  8. Drug

    Doxorubicin

    go.drugbank.com/drugs/DB00997
    ApprovedInvestigational

    cumulative dose is reached. … Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.

    Categories: Topoisomerase II InhibitorsSynonyms: (1S,3S)-3-glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside, (8S-cis)-10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
  9. Drug

    Succinylcholine

    go.drugbank.com/drugs/DB00202
    ApprovedInvestigational

    [A19054] It has been widely used for over 50 years,[A299] most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures. … Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups.

    Products: Suxamethonium Aguettant 10 mg/ml Injektionslösung in einer Fertigspritze, Anectine Inj 20mg/ml
  10. Drug

    Trabectedin

    go.drugbank.com/drugs/DB05109
    ApprovedInvestigational

    It is approved for use in Europe, Russia and South Korea for the treatment of advanced soft tissue sarcoma. … It is currently under evaluation for the treatment of breast cancer, prostate cancer, in addition to pediatric sarcomas. Both the European Commission and the U.S.

    Products: YONDELIS 1 MG IV KONSANTRE INFUZYONLUK COZELTI ICIN TOZ