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Mitogen-activated protein kinase kinase kinase 5
go.drugbank.com/bio_entities/BE0018876TargetHumansBoth p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1)
Polypeptides: Mitogen-activated protein kinase kinase kinase 5Synonyms: ASK-1, Apoptosis signal-regulating kinase 1T cell receptor beta variable 5-6
go.drugbank.com/bio_entities/BE0023691TargetHumansV region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and ...
Polypeptides: T cell receptor beta variable 5-6NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
go.drugbank.com/bio_entities/BE0000089TargetHumansAccessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The ...
Polypeptides: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
go.drugbank.com/bio_entities/BE0000436TargetHumansCyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has ...
Polypeptides: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3AFunction: 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activityType II inositol 1,4,5-trisphosphate 5-phosphatase
go.drugbank.com/bio_entities/BE0004437TargetHumansAlso hydrolyzes the 5-position phosphate from inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), thereby modulating cellular signaling events … Regulates phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) cellular levels by cleaving the phosphate at the 5-position producing PtdIns(4)P.
Polypeptides: Type II inositol 1,4,5-trisphosphate 5-phosphataseSynonyms: Phosphoinositide 5-phosphatase, 75 kDa inositol polyphosphate-5-phosphataseInsulin-like growth factor-binding protein 5
go.drugbank.com/bio_entities/BE0009661CarrierHumansMultifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type spe...
Polypeptides: Insulin-like growth factor-binding protein 5Synonyms: IBP-5, IGFBP-5Levamlodipine
go.drugbank.com/drugs/DB09237ApprovedInvestigationalLevamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. … [L10833] As a racemic mixture, amlodipine contains (R) and (S)-amlodipine isomers, but only (S)-amlodipine as the active moiety possesses therapeutic activity.
Mixtures: VOLTRAMOS 5 MG/160 MG FILM KAPLI TABLET, 28 ADET, ALENCAL VALS 5/320 MG TABLETAS RECUBIERTASCategories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substratesLenvatinib
go.drugbank.com/drugs/DB09078ApprovedInvestigationalMost patients with thyroid cancer have a very good prognosis with treatment (98% 5 year survival rate) involving surgery and hormone therapy. … factor (FGF) receptors FGFR1, 2, 3, and 4; the platelet derived growth factor receptor alpha (PDGFRα), KIT, and RET.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamideBenperidol
go.drugbank.com/drugs/DB12867ApprovedWithdrawnBenperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.
Products: BENPERIDOL-NEURAX 2 MG, BENPERIDOL-NEURAX 4 MGAcalabrutinib
go.drugbank.com/drugs/DB11703ApprovedInvestigationalunmet medical need based on a surrogate endpoint. … [L10241] In August 2022, the FDA approved a new tablet formulation of Calquence, enabling the co-administration of this drug with proton pump inhibitors (PPIs).
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: CALQUENCE 100 MG SERT KAPSÜL, 56 ADET, CALQUENCE® 100MG