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Vemurafenib
go.drugbank.com/drugs/DB08881ApprovedInvestigationalAfter approval, Roche in collaboration with Genentech launched a broad development program. [L1012] … Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E.[A31269] It exerts its function by binding to the ATP-binding domain of the mutant BRAF.
Categories: Heterocyclic Compounds, 2-Ring, P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: ZELBORAF ® TABLETAS LACADAS DE 240 MG, ZELBORAF 240 MG FILM KAPLI TABLET ,56 FILM KAPLI TABLETPramipexole
go.drugbank.com/drugs/DB00413ApprovedInvestigationalliving due to symptoms that progress over time [A176858]. … Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD).
Categories: Heterocyclic Compounds, 2-Ring, Heterocyclic Compounds, 1-RingSynonyms: (S)-N 6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamineSodium fluoride
go.drugbank.com/drugs/DB09325ApprovedInvestigationalNow, sodium fluoride may be found in a variety of gels, varnishes, rinses, toothpaste products, and fluoride treatments provided in dental care. … Sodium fluoride is an inorganic chemical compound that is a source of the fluoride ion in many applications, including dental care and radiographic imaging when it is used as [Fluoride ion F-18].
Mixtures: PREVENT 2 EN 1, Florafol FE Pediatric 0.25 mg/mL Multivitamin and Fluoride Liquid DropsCategories: Compounds used in a research, industrial, or household settingPotassium acetate
go.drugbank.com/drugs/DB14498ApprovedMixtures: Normosol-M & 5% Dextrose, AMINOPLASMAL-5% E INFUSIONProducts: DBL POTASSIUM ACETATE CONCENTRATED INJECTION 2.45 g/5 ml, Potassium Acetate Inj 2meq/mlPyrroline-5-carboxylate reductase 1, mitochondrial
go.drugbank.com/bio_entities/BE0000225TargetHumansOxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H (PubMed:16730026, PubMed:19648921, PubMed:23024808
Polypeptides: Pyrroline-5-carboxylate reductase 1, mitochondrial3',5'-cyclic-AMP phosphodiesterase 4D
go.drugbank.com/bio_entities/BE0001287TargetHumansHydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes
Polypeptides: 3',5'-cyclic-AMP phosphodiesterase 4DFunction: 3',5'-cyclic-AMP phosphodiesterase activitycGMP-dependent 3',5'-cyclic phosphodiesterase
go.drugbank.com/bio_entities/BE0002085TargetHumanscGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15938621, PubMed:29392776, PubMed:9210593). Ha...
Polypeptides: cGMP-dependent 3',5'-cyclic phosphodiesteraseFunction: 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activitytRNA (cytosine(38)-C(5))-methyltransferase
go.drugbank.com/bio_entities/BE0002517TargetHumansSpecifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) (PubMed:16424344). Has higher activity on tRNA(Asp) modified with queuosine at position 34 (PubMed:30093495)
Polypeptides: tRNA (cytosine(38)-C(5))-methyltransferaseSynonyms: DNA (cytosine-5)-methyltransferase-like protein 2Trafficking protein particle complex subunit 5
go.drugbank.com/bio_entities/BE0004277TargetHumansMay play a role in vesicular transport from endoplasmic reticulum to Golgi
Polypeptides: Trafficking protein particle complex subunit 5Pregnancy-specific beta-1-glycoprotein 5
go.drugbank.com/bio_entities/BE0008996TargetHumansPolypeptides: Pregnancy-specific beta-1-glycoprotein 5Synonyms: PSBG-5, PS-beta-G-5