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Displaying results 551 - 560 of 10000 in total
  1. Drug

    Elenestinib

    go.drugbank.com/drugs/DB18489
    Investigational

    Elenestinib is a selective KIT inhibitor.

    Synonyms: (S)-2-(4-(4-(4-(5-(1-amino-1-(4-fluorophenyl)ethyl)pyrimidin-2-yl)piperazin-1-yl)pyrrolo[2,1-f][1,2,4]triazin-6-yl)-1H-pyrazol-1-yl)ethan-1-ol, 1H-Pyrazole-1-ethanol, 4-[4-[4-[5-[(1S)-1-amino-1-(4-fluorophenyl)ethyl]-2-pyrimidinyl]-1-piperazinyl]pyrrolo[2,1-f][1,2,4]triazin-6-yl]-
  2. Indication

    Severe, active Crohn´s Disease

    go.drugbank.com/conditions/DBCOND0123591
    Drugs: Guselkumab · Risankizumab · Upadacitinib · Ustekinumab
    Synonyms: Severe, active Crohn´s Disease
  3. Drug

    Amantadine

    go.drugbank.com/drugs/DB00915
    ApprovedInvestigational

    An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia.

    Synonyms: 1-adamantanamine, 1-adamantylamineInternational brands: PK-Merz
  4. Target

    Glutathione S-transferase Mu 1

    go.drugbank.com/bio_entities/BE0000807
    TargetEnzymeHumans

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). ...

    Polypeptides: Glutathione S-transferase Mu 1
  5. Target

    Glutathione S-transferase theta-1

    go.drugbank.com/bio_entities/BE0000818
    TargetEnzymeHumans

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays...

    Polypeptides: Glutathione S-transferase theta-1
  6. Target

    G1/S-specific cyclin-D1

    go.drugbank.com/bio_entities/BE0001027
    TargetHumans

    Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition

    Polypeptides: G1/S-specific cyclin-D1
  7. Target

    Glutathione S-transferase 3, mitochondrial

    go.drugbank.com/bio_entities/BE0002279
    TargetEnzymeHumans

    Displays both glutathione S-transferase and glutathione peroxidase activities toward oxyeicosanoids, as part of cellular detoxification as well as synthesis of bioactive metabolites (PubMed:36370807, PubMed

    Polypeptides: Glutathione S-transferase 3, mitochondrial
  8. Target

    Glutathione S-transferase Mu 5

    go.drugbank.com/bio_entities/BE0002285
    TargetEnzymeHumans

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles

    Polypeptides: Glutathione S-transferase Mu 5
  9. Target

    Microsomal glutathione S-transferase 2

    go.drugbank.com/bio_entities/BE0002290
    TargetEnzymeHumans

    Catalyzes several different glutathione-dependent reactions (PubMed:23409838, PubMed:26066610, PubMed:26656251, PubMed:8703034, PubMed:9278457). Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (PubM...

    Polypeptides: Microsomal glutathione S-transferase 2Synonyms: Microsomal glutathione S-transferase II
  10. Target

    Glutathione S-transferase omega-2

    go.drugbank.com/bio_entities/BE0002291
    TargetHumans

    Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monometh...

    Polypeptides: Glutathione S-transferase omega-2Synonyms: Glutathione S-transferase omega 2-2