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Displaying results 5671 - 5680 of 10000 in total
  1. Drug

    Atropine

    go.drugbank.com/drugs/DB00572
    ApprovedInvestigationalVet approved

    Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active. … [A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosseous, endotracheal and ophthalmic methods.

    Synonyms: dl-Hyoscyamine, dl-tropyltropateMixtures: PHARMANIAGA DIPHENOXYLATE A TABLET, Re-PB Hyos
  2. Drug

    Ibandronate

    go.drugbank.com/drugs/DB00710
    ApprovedInvestigational

    [L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatment for bone loss in dogs.[A203138] Ibandronate was granted FDA approval on 16 May 2003.[L13805] … Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].

    Mixtures: IBONE D®, IBONE D 30000Products: BONDRONAT® CONCENTRADO DE SOLUCION PARA INFUSION 6 MG/6ML., ASCENDRA 3MG DUO D3 1 + 90
  3. Drug

    Zoledronic acid

    go.drugbank.com/drugs/DB00399
    ApprovedInvestigational

    Zoledronic acid, or CGP 42'446,[A203120] is a third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and [risedronic acid].

    Salts: Zoledronate D,L-Lysine MonohydrateCategories: Heterocyclic Compounds, 1-Ring
  4. Indication

    Ankle spasticity following a stroke or traumatic brain injury

    go.drugbank.com/conditions/DBCOND0133858
    Drugs: Clostridium botulinum
    Synonyms: Ankle spasticity following a stroke or traumatic brain injury
  5. Drug

    Hydrogenated soybean lecithin

    go.drugbank.com/drugs/DB14157
    Investigational

    Synonyms: Soya lecithin, hydrogenated, Soya lecithins, hydrogenated
  6. Target

    3-hydroxy-3-methylglutaryl-coenzyme A reductase

    go.drugbank.com/bio_entities/BE0000574
    TargetEnzymeHumans

    HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668, PubMed:36745799) … Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular

    Polypeptides: 3-hydroxy-3-methylglutaryl-coenzyme A reductaseFunction: coenzyme A binding
  7. Target

    Acetyl-coenzyme A synthetase 2-like, mitochondrial

    go.drugbank.com/bio_entities/BE0000746
    TargetHumans

    Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity) … Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity).

    Polypeptides: Acetyl-coenzyme A synthetase 2-like, mitochondrial
  8. Target

    2-amino-3-ketobutyrate coenzyme A ligase

    go.drugbank.com/bio_entities/BE0002049
    TargetEscherichia coli (strain K12)

    Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.

    Polypeptides: 2-amino-3-ketobutyrate coenzyme A ligase
  9. Target

    2,5-diketo-D-gluconic acid reductase A

    go.drugbank.com/bio_entities/BE0002618
    TargetCorynebacterium sp. (strain ATCC 31090)

    Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates. 25DKGR-A exhibits a greater selectivity

    Polypeptides: 2,5-diketo-D-gluconic acid reductase ASynonyms: 2,5-DKG reductase A
  10. Target

    A-type voltage-gated potassium channel KCND2

    go.drugbank.com/bio_entities/BE0003603
    TargetHumans

    In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. … Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity).

    Polypeptides: A-type voltage-gated potassium channel KCND2Function: A-type (transient outward) potassium channel activity