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Displaying results 561 - 570 of 10000 in total
  1. Pathway

    Intracellular Signalling Through Adenosine Receptor A2b and Adenosine

    smpdb.ca/view/SMP0000321
    Signaling

    Adenosine is thought to play a role in the pathophysiology of asthma. Stimulation of A2B can induce production of interleukin-8 mast cells. The adenosine receptor A2b activates G(s) proteins which lead to the activation of adenylyl cycla...

    Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid
  2. Pathway

    Metabolism and Physiological Effects of 2-Aminobenzoic acid

    smpdb.ca/view/SMP0126869
    Disease

    Outside of the human body, 2-Aminobenzoic acid has been detected, but not quantified in several different foods, such as mamey sapotes, prairie turnips, rowals, natal plums, and hyacinth beans. … Uremic syndrome may affect any part of the body and can cause nausea, vomiting, loss of appetite, and weight loss.

    Drugs: Tryptophan · Alanine · Formic acid · Kynurenine · Mesoheme · Anthranilic acid +1 more
    Enzymes: Neutral and basic amino acid transport protein rBAT
  3. Pathway

    Metabolism and Physiological Effects of 4-Hydroxyphenylacetic acid

    smpdb.ca/view/SMP0126879
    Metabolic

    It is also a parent compound for other transformation products, including but not limited to, methyl 2-(4-hydroxyphenyl)acetate, ixerochinolide, and lactucopicrin 15-oxalate. … , and C. propionicum. l-tyrosine, derived from diet and endogenous proteins and peptides, can be converted to phenol and 4-hydroxyphenylpyruvate.

    Drugs: Pyridoxal phosphate · Tyrosine · Glutamic acid · P-Cresol · Oxogluric acid · 4-Hydroxyphenylpyruvic acid
  4. Drug

    Calcium polycarbophil

    go.drugbank.com/drugs/DB14684
    Approved

    Less gas and bloating compared to psyllium laxative products, but can cause heartburn, and belly cramps. It is insoluble in water, dilute acids, and dilute alkali. … is physiologically inert, and does not cause gastrointestinal irritation.

    Categories: Alimentary Tract and MetabolismProducts: Up and Up Fiber Therapy, Foster and Thrive Fiber Laxative 147
  5. Drug

    Pasireotide

    go.drugbank.com/drugs/DB06663
    ApprovedInvestigational

    Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease.

    Synonyms: cyclo((4R)-4-(2-aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-D-tryptophyl-L-lysyl-4-O-benzyl-L-tyrosyl-L- phenylalanyl-)Categories: Pituitary and Hypothalamic Hormones and Analogues, Sex Hormones and Insulins
  6. Drug

    Pralatrexate

    go.drugbank.com/drugs/DB06813
    ApprovedInvestigational

    [A246693] Pralatrexate is designed to have a higher affinity for the reduced folate carrier, a protein that is overexpressed in malignant cells and is upregulated by oncogenes. … [A246703] Pralatrexate was approved by the FDA on September 24, 2009.

    Categories: Antineoplastic and Immunomodulating AgentsSynonyms: (2S)-2-((4-((1RS)-1-((2,4-Diaminopteridin-6-yl)methyl)but-3-ynyl)benzoyl)amino)pentanedioic acid, N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid
  7. Drug

    Diflunisal

    go.drugbank.com/drugs/DB00861
    Approved

    Diflunisal is used to relieve pain accompanied with inflammation and in the symptomatic treatment of rheumatoid arthritis and osteoarthritis. … Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity.

    Categories: Salicylic Acid and Derivatives, Anti-Inflammatory Agents, Non-Steroidal (Non-Selective)Products: Nu-diflunisal Tab 250mg, Dolobid Tab 250mg
  8. Drug

    Infliximab

    go.drugbank.com/drugs/DB00065
    ApprovedInvestigational

    By binding to both the soluble subunit and the membrane-bound precursor of TNF-α [A106], infliximab disrupts the interaction of TNF-α with its receptors and may also cause lysis of cells that produce TNF-α … Infliximab was first approved by the FDA in 1998 under the market name Remicade as an intravenous injection.

    Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: INFLECTRA 100MG PLV F E KO, REMICADE 100MG PULV F E KO
  9. Drug

    Sibutramine

    go.drugbank.com/drugs/DB01105
    ApprovedIllicitWithdrawn

    In October 2010, Sibutramine was withdrawn from Canadian and U.S. markets due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease. … Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity.

    Categories: Alimentary Tract and Metabolism, Serotonin and Noradrenaline Reuptake InhibitorsProducts: SIBUTRAMINA 15MG, SIBUTRAMINA 15MG CAPSULA
  10. Drug

    Valerian

    go.drugbank.com/drugs/DB13196
    Approved

    Valerian root is reported to have sedative and anxiolytic effects however its mechanism of action is not completely understood. … Valerian has been used in the treatment of conditions including sleep disorders, anxiety, attention deficit-hyperactivity disorder (ADHD) and joint pain.

    Mixtures: Bio-strath No. 8 Gouttes, Valerian and Hops TabletsCategories: Hypnotics and Sedatives, Herbs and Natural Products