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Displaying results 571 - 580 of 1186 in total
  1. Target

    Uracil nucleotide/cysteinyl leukotriene receptor

    go.drugbank.com/bio_entities/BE0010169
    TargetHumans

    Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase.

    Polypeptides: Uracil nucleotide/cysteinyl leukotriene receptorSynonyms: P2Y-like receptor, UDP/CysLT receptor
  2. Target

    Platelet-derived growth factor receptor

    go.drugbank.com/bio_entities/BE0010249
    TargetHumans

    Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor … Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor

    Polypeptides: Platelet-derived growth factor receptor alpha, Platelet-derived growth factor receptor betaSynonyms: Alpha platelet-derived growth factor receptor, Platelet-derived growth factor receptor 2
  3. Target

    Aryl hydrocarbon receptor nuclear translocator

    go.drugbank.com/bio_entities/BE0010296
    TargetHumans

    Forms heterodimers with the aryl hydrocarbon receptor (AHR) to mediate the transcriptional response to xenobiotics by binding xenobiotic response elements (XREs) or dioxin response elements (DREs) in target

    Polypeptides: Aryl hydrocarbon receptor nuclear translocatorSynonyms: Dioxin receptor, nuclear translocator
  4. Target

    Interleukin-1 receptor accessory protein

    go.drugbank.com/bio_entities/BE0010488
    TargetHumans

    Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. … The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system.

    Polypeptides: Interleukin-1 receptor accessory proteinSynonyms: Interleukin-1 receptor 3, IL-1 receptor accessory protein
  5. Target

    Interleukin-15 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0010620
    TargetHumans

    High-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity).

    Polypeptides: Interleukin-15 receptor subunit alphaSynonyms: IL-15 receptor subunit alpha
  6. Target

    GDNF family receptor alpha-3

    go.drugbank.com/bio_entities/BE0011826
    TargetHumans

    ARTN-binding leads to autophosphorylation and activation of the RET receptor (PubMed:31535977, PubMed:9883723) … Receptor for artemin (ARTN), a growth factor that supports the survival of sensory and sympathetic peripheral neurons (PubMed:31535977, PubMed:9883723).

    Polypeptides: GDNF family receptor alpha-3Synonyms: GDNF receptor alpha-3
  7. Target

    Vasoactive intestinal polypeptide receptor 2

    go.drugbank.com/bio_entities/BE0013151
    TargetHumans

    G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:7811244, PubMed:35477937, PubMed

    Polypeptides: Vasoactive intestinal polypeptide receptor 2Synonyms: VPAC2 receptor, PACAP type III receptor
  8. Target

    Interleukin-1 receptor-like 1

    go.drugbank.com/bio_entities/BE0013861
    TargetHumans

    Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP

    Polypeptides: Interleukin-1 receptor-like 1Function: cytokine receptor activity
  9. Target

    Interleukin-10 receptor subunit beta

    go.drugbank.com/bio_entities/BE0014312
    TargetHumans

    Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. … The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity.

    Polypeptides: Interleukin-10 receptor subunit betaSynonyms: IL-10 receptor subunit beta, Cytokine receptor class-II member 4
  10. Target

    TNF receptor-associated factor 6

    go.drugbank.com/bio_entities/BE0021309
    TargetHumans

    Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (PubMed:12140561, PubMed:19825828, PubMed:8837778).

    Polypeptides: TNF receptor-associated factor 6