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Lysophosphatidylcholine acyltransferase 2
go.drugbank.com/bio_entities/BE0016122TargetEnzymeHumansAlso converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (By similarity). … Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position
Polypeptides: Lysophosphatidylcholine acyltransferase 2Synonyms: LPCAT-2, LPC acyltransferase 2Adenosine deaminase 2
go.drugbank.com/bio_entities/BE0020559EnzymeHumansAdenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surf...
Polypeptides: Adenosine deaminase 2Interleukin-2 receptor
go.drugbank.com/bio_entities/BE0027978TargetHumansReceptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. … Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.
Polypeptides: Interleukin-2 receptor subunit alpha, Interleukin-2 receptor subunit betaSynonyms: IL-2-RA, IL-2 receptor subunit gammaATP-binding cassette sub-family B member 5
go.drugbank.com/bio_entities/BE0002369TargetTransporterHumansEnergy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:12960149, PubMed:15205344, PubMed:15899824, PubMed:22306008). Specifically present in limbal stem cells, where it plays ...
Polypeptides: ATP-binding cassette sub-family B member 5Potassium voltage-gated channel subfamily KQT member 5
go.drugbank.com/bio_entities/BE0002400TargetHumansPore-forming subunit of the voltage-gated potassium (Kv) channel broadly expressed in brain and involved in the regulation of neuronal excitability (PubMed:10787416, PubMed:10816588, PubMed:11159685, PubMed:28669405). Associates with KCN...
Polypeptides: Potassium voltage-gated channel subfamily KQT member 5Synonyms: KQT-like 5Rod cGMP 3',5'-cyclic phosphodiesterase subunit gamma
go.drugbank.com/bio_entities/BE0003556TargetHumansInhibitory gamma subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade.
Polypeptides: Rod cGMP 3',5'-cyclic phosphodiesterase subunit gammaFunction: 3',5'-cyclic-nucleotide phosphodiesterase activityATP-binding cassette sub-family C member 5
go.drugbank.com/bio_entities/BE0003639TransporterTargetHumansATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid a...
Polypeptides: ATP-binding cassette sub-family C member 5Synonyms: Multidrug resistance-associated protein 5Potassium voltage-gated channel subfamily A member 5
go.drugbank.com/bio_entities/BE0004717TargetHumansVoltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. Th...
Polypeptides: Potassium voltage-gated channel subfamily A member 5ATP-binding cassette sub-family G member 5
go.drugbank.com/bio_entities/BE0004750TransporterHumansABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:27144356).
Polypeptides: ATP-binding cassette sub-family G member 5Dual specificity mitogen-activated protein kinase kinase 5
go.drugbank.com/bio_entities/BE0009460TargetHumansActs as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac d...
Polypeptides: Dual specificity mitogen-activated protein kinase kinase 5Synonyms: MEK 5, MAPKK 5