ATP-binding cassette sub-family C member 5

BE0003639ProteinHumansABCC5

ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. It is acted on by 19 drugs in DrugBank.

Gene name
ABCC5
UniProtKB entry
O15440Swiss-Prot
Cellular location
Basolateral cell membrane
Residues / weight
1,437 residues · 160,659 Da
Also known as
7.6.2.- · 7.6.2.2 · MOAT-C · MRP5 · Multi-specific organic anion transporter C

Resolves to

Protein
UniProtO15440UniProt nameMRP5_HUMAN
Gene
HGNCHGNC:56NCBI Gene10057GenBank4140698GeneCardsABCC5
Pharmacology
IUPHAR/GtoPdb783KEGGhsa:10057
Structure
PDB8KCIPDB8WI0PDB8WI2
Drugs

What you can answer from here — as of September 03, 2024

19DrugsApproved to experimental, with action, bond type and pharmacological action
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27GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-binding cassette sub-family C member 5, how selective are they, and which programs against it are still in active trials?

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