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Displaying results 5801 - 5810 of 10000 in total
  1. Target

    ATP-binding cassette sub-family G member 5

    go.drugbank.com/bio_entities/BE0004750
    TransporterHumans

    ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:27144356).

    Polypeptides: ATP-binding cassette sub-family G member 5
  2. Target

    Dual specificity mitogen-activated protein kinase kinase 5

    go.drugbank.com/bio_entities/BE0009460
    TargetHumans

    Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac d...

    Polypeptides: Dual specificity mitogen-activated protein kinase kinase 5Synonyms: MEK 5, MAPKK 5
  3. Target

    5'-AMP-activated protein kinase subunit gamma-1

    go.drugbank.com/bio_entities/BE0009988
    TargetHumans

    AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:21680840, PubMed:24563466). In response to reduction of intracellular ...

    Polypeptides: 5'-AMP-activated protein kinase subunit gamma-1
  4. Target

    3-oxo-5-alpha-steroid 4-dehydrogenase 1

    go.drugbank.com/bio_entities/BE0000539
    TargetEnzymeHumans

    Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed … Converts testosterone into 5-alpha-dihydrotestosterone (DHT), a more potent androgen as it is the preferred ligand for androgen receptor (AR) transactivation, making this reaction a key step in male sexual

    Polypeptides: 3-oxo-5-alpha-steroid 4-dehydrogenase 1Synonyms: Steroid 5-alpha-reductase 1
  5. Target

    High affinity 3',5'-cyclic-AMP phosphodiesterase 7A

    go.drugbank.com/bio_entities/BE0000706
    TargetHumans

    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:19350606, PubMed:8389765, PubMed:9195912). May have a role in muscle signal transduction (PubMed:9195912)

    Polypeptides: High affinity 3',5'-cyclic-AMP phosphodiesterase 7AFunction: 3',5'-cyclic-AMP phosphodiesterase activity
  6. Target

    Mitogen-activated protein kinase kinase kinase kinase 5

    go.drugbank.com/bio_entities/BE0009474
    TargetHumans

    May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway

    Polypeptides: Mitogen-activated protein kinase kinase kinase kinase 5Synonyms: MEKKK 5, MEK kinase kinase 5
  7. Target

    Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

    go.drugbank.com/bio_entities/BE0014411
    TargetHumans

    Also has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). … Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity

    Polypeptides: Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRNSynonyms: RecQ protein-like 2
  8. Drug

    Mepolizumab

    go.drugbank.com/drugs/DB06612
    ApprovedInvestigational

    Eosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically defined as absolute eosinophil levels of 1500/mm<sup>3</sup> or more) is associated with a spectrum … [A221048, A221053, A221058, A221063, A221068, L16518] Mepolizumab is a fully-humanized recombinant IgG1 kappa monoclonal antibody directed against IL-5 produced in Chinese hamster ovary cells.

    Categories: Interleukin-5 AntagonistProducts: NUCALA 100 MG/ML SC ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 ADET, NUCALA 100 MG/ML SC ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR, 3 ADET
  9. Drug

    Iron protein succinylate

    go.drugbank.com/drugs/DB11209
    Approved

    Mixtures: KOMFER FOL 40 MG/185 MCG ORAL COZELTI, 20 FLK., FERPLEX FOL 40 MG + 0.185 MG/15 ML ORAL ÇÖZELTİ, 10 ADETProducts: KOMFER 40 MG ORAL ÇÖZELTİ, 15 ML X 20 FLAKON, FERBEST 40 MG/15 ML ORAL COZELTI ,20 FLAKON
  10. Drug

    Cianidanol

    go.drugbank.com/drugs/DB14086
    ApprovedInvestigationalWithdrawn

    An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.

    Categories: Heterocyclic Compounds, 2-Ring, Heterocyclic Compounds, 1-RingSynonyms: d-Catechin, D-Catechol