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P2X purinoceptor 2
go.drugbank.com/bio_entities/BE0009820TargetHumansATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:10570044, PubMed:31636190). Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic r...
Polypeptides: P2X purinoceptor 2NADPH oxidase 2
go.drugbank.com/bio_entities/BE0009985TargetHumansCatalytic subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:15338276, PubMed:36241643, PubMed:36413210, PubMed:38355798). In ...
Polypeptides: NADPH oxidase 2Sphingomyelin phosphodiesterase 2
go.drugbank.com/bio_entities/BE0012101TargetHumansAlso hydrolyzes 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor) in vivo (PubMed:10608884). … Also acts on 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and sphingosylphosphocholine (PubMed:10608884, PubMed:14741383)
Polypeptides: Sphingomyelin phosphodiesterase 2Phosphatidylcholine:ceramide cholinephosphotransferase 2
go.drugbank.com/bio_entities/BE0017188TargetEnzymeHumansSphingomyelin synthase that primarily contributes to sphingomyelin synthesis and homeostasis at the plasma membrane. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transf...
Polypeptides: Phosphatidylcholine:ceramide cholinephosphotransferase 2Synonyms: Sphingomyelin synthase 2Relaxin receptor 2
go.drugbank.com/bio_entities/BE0017729TargetHumansReceptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3)
Polypeptides: Relaxin receptor 2Synonyms: Relaxin family peptide receptor 2Protein argonaute-2
go.drugbank.com/bio_entities/BE0020979TargetHumansRequired for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide R...
Polypeptides: Protein argonaute-2Synonyms: eIF2C 2, eIF-2C 2Carbonic anhydrase 2
go.drugbank.com/bio_entities/BE0000322TargetEnzymeCarrierHumansCatalyzes the reversible hydration of carbon dioxide (PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:1586543...
Polypeptides: Carbonic anhydrase 2Monocarboxylate transporter 2
go.drugbank.com/bio_entities/BE0000440TargetTransporterHumansProton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:32415067, PubMed...
Polypeptides: Monocarboxylate transporter 2Synonyms: MCT 2Antizyme inhibitor 2
go.drugbank.com/bio_entities/BE0000448TargetHumansAntizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 a...
Polypeptides: Antizyme inhibitor 2Retinal dehydrogenase 2
go.drugbank.com/bio_entities/BE0000513TargetHumansCatalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively (...
Polypeptides: Retinal dehydrogenase 2Synonyms: RALDH 2, Retinaldehyde-specific dehydrogenase type 2