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Displaying results 5871 - 5880 of 10000 in total
  1. Drug

    Atorvastatin

    go.drugbank.com/drugs/DB01076
    ApprovedInvestigational

    the number of major cardiovascular events (heart attack, stroke, coronary revascularization, and coronary death) for every 1 mmol/L reduction in LDL without any significant side effects or risks. … More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[A181421] which catalyzes the conversion of HMG-CoA to mevalonic acid.

    Mixtures: Triveram 20 mg/5 mg/5 mg Filmtabletten, TRIVERAM FILM-COATED TABLET 20 mg/5 mg/5 mgCategories: P-glycoprotein inhibitors, P-glycoprotein substrates
  2. Drug

    Pentoxyverine

    go.drugbank.com/drugs/DB11186
    ApprovedWithdrawn

    Pentoxyverine acts on sigma-1 receptors, as well as kappa and mu-opioid receptors. The FDA withdrew the use of all oral gel drug products containing pentoxyverine citrate. … Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant [A32717], and local anesthetic properties.

    Mixtures: Exall D, Zotex-DProducts: PENTOXYVERIN AL 1.35 MG/ML, Mucomat Hustenstiller 2,13 mg/ml Lösung zum Einnehmen
  3. Pathway

    Acylcarnitine (5Z)-7-[(1S,5E)-5-[(2E)-oct-2-en-1-ylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoylcarnitine

    smpdb.ca/view/SMP0123550
    Metabolic

    (5Z)-7-[(1S,5E)-5-[(2E)-oct-2-en-1-ylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoylcarnitine is an acylcarnitine. … membrane to once again form (5Z)-7-[(1S,5E)-5-[(2E)-oct-2-en-1-ylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoyl-CoA and L-carnitine. (5Z)-7-[(1S,5E)-5-[(2E)-oct-2-en-1-ylidene]-4-oxocyclopent-2-en-1-yl]

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Solute carrier family 22 member 5, Carnitine O-palmitoyltransferase 2, mitochondrial
  4. Target

    5'-AMP-activated protein kinase subunit beta-1

    go.drugbank.com/bio_entities/BE0000254
    TargetHumans

    Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-pro...

    Polypeptides: 5'-AMP-activated protein kinase subunit beta-1
  5. Target

    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

    go.drugbank.com/bio_entities/BE0000473
    TargetHumans

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The ...

    Polypeptides: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
  6. Target

    A disintegrin and metalloproteinase with thrombospondin motifs 5

    go.drugbank.com/bio_entities/BE0003730
    TargetHumans

    Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chon...

    Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 5Synonyms: ADMP-2, ADAMTS-5
  7. Target

    cAMP-specific 3',5'-cyclic phosphodiesterase 4 (PDE4)

    go.drugbank.com/bio_entities/BE0009963
    TargetHumans

    Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes

    Polypeptides: 3',5'-cyclic-AMP phosphodiesterase 4A, 3',5'-cyclic-AMP phosphodiesterase 4BFunction: 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-AMP phosphodiesterase activity
  8. Drug

    Exametazime

    go.drugbank.com/drugs/DB11179
    Approved

    It acts as a chelating agent for the radioisotope technetium-99m to form a cationic complex. … Exametazime is a diagnostic radiopharmaceutical agent commonly used for the preparation of Tc99m Exametazime injection.

    Products: CERETEC FOR INJECTION 0.5 mg/vial, BRAIN - SPECT®
  9. Drug

    Peanut oil

    go.drugbank.com/drugs/DB13964
    ApprovedWithdrawn

    The peanut oil represents about 45-52% of the kernel content and it is mainly formed from monounsaturated fat from which the major component is [DB04224]. … The kernels are consumed roasted but a large percentage is used for the production of vegetable oil.

    Products: Oilatum Soap - 2%
  10. Drug

    Clopidogrel

    go.drugbank.com/drugs/DB00758
    ApprovedInvestigational

    Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke. … L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI

    Mixtures: ATELIT-DUO® 75/100 MG TABLETAS, KLOGEL-A 75/75 MG KAPSUL, 30 ADETCategories: Heterocyclic Compounds, 2-Ring, P-glycoprotein substrates