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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
go.drugbank.com/bio_entities/BE0003717TargetHumansBinding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). … Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299)
Polypeptides: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8ALeucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
go.drugbank.com/bio_entities/BE0018277TargetHumansIs also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). … Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity)
Polypeptides: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1Synonyms: Leucine-rich repeat and immunoglobulin domain-containing protein 1Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
go.drugbank.com/bio_entities/BE0004631TargetHumansHyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). … Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity).
Polypeptides: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
go.drugbank.com/bio_entities/BE0010899TargetHumansHyperpolarization-activated ion channel that are permeable to sodium and potassium ions (PubMed:15351778, PubMed:28086084). Displays lower selectivity for K(+) over Na(+) ions (PubMed:28086084). … Contributes to the native pacemaker currents in heart (If) and in the generation of the I(h) current which controls neuron excitability (PubMed:29936235, PubMed:30351409).
Polypeptides: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
go.drugbank.com/bio_entities/BE0020615TargetHumansHyperpolarization-activated ion channel that are permeable to sodium and potassium ions, with an about 3:1 preference for potassium ions (PubMed:16043489). … Contributes to the native pacemaker currents in heart (If) and in neurons (Ih).
Polypeptides: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
go.drugbank.com/bio_entities/BE0021454TargetHumansHyperpolarization-activated ion channel that are permeable to Na(+) and K(+) ions with very slow activation and inactivation (PubMed:10228147, PubMed:10430953, PubMed:20829353).
Polypeptides: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4Chondroitin sulfate proteoglycan 4
go.drugbank.com/bio_entities/BE0015621TargetHumansMay stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades … May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate.
Polypeptides: Chondroitin sulfate proteoglycan 4Synonyms: Chondroitin sulfate proteoglycan NG2, Melanoma chondroitin sulfate proteoglycanSodium channel protein
go.drugbank.com/bio_entities/BE0004901TargetHumansSodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. … While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient (PubMed:26537257, PubMed:35301303).
Polypeptides: Sodium channel protein type 1 subunit alpha, Sodium channel protein type 10 subunit alphaSynonyms: Peripheral nerve sodium channel 3, Peripheral sodium channel 1