Search

Displaying results 51 - 60 of 606 in total
  1. Target

    Transcription factor IIIA

    go.drugbank.com/bio_entities/BE0023044
    TargetHumans

    It is required for their RNA polymerase III-dependent transcription and may also maintain the transcription of other genes (PubMed:24120868). Also binds the transcribed 5S RNA's (By similarity)

    Polypeptides: Transcription factor IIIA
  2. Target

    Tumor necrosis factor

    go.drugbank.com/bio_entities/BE0000704
    TargetHumans

    and induce cell differentiation. … Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines.

    Polypeptides: Tumor necrosis factorSynonyms: Tumor necrosis factor ligand superfamily member 2
  3. Target

    Transcription factor Jun

    go.drugbank.com/bio_entities/BE0001040
    TargetHumans

    Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). … Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional

    Polypeptides: Transcription factor JunSynonyms: Transcription factor AP-1 subunit Jun
  4. Target

    Hepatocyte growth factor

    go.drugbank.com/bio_entities/BE0001121
    TargetHumans

    Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types (PubMed:20624990). … Activates MAPK signaling following TMPRSS13 cleavage and activation (PubMed:20977675)

    Polypeptides: Hepatocyte growth factorSynonyms: Scatter factor
  5. Target

    Platelet factor 4

    go.drugbank.com/bio_entities/BE0001129
    TargetHumans

    Chemotactic for neutrophils and monocytes via CCR1 (PubMed:29930254). Inhibits endothelial cell proliferation. … Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence (PubMed:9531587).

    Polypeptides: Platelet factor 4
  6. Target

    Elongation factor G

    go.drugbank.com/bio_entities/BE0001796
    TargetThermus thermophilus

    the P and E sites, respectively. … Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.

    Polypeptides: Elongation factor G
  7. Target

    Placenta growth factor

    go.drugbank.com/bio_entities/BE0003148
    TargetHumans

    Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. … Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth

    Polypeptides: Placenta growth factor
  8. Target

    Elongation factor Tu

    go.drugbank.com/bio_entities/BE0003279
    TargetThermus aquaticus

    This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

    Polypeptides: Elongation factor Tu
  9. Target

    Elongation factor 2

    go.drugbank.com/bio_entities/BE0004281
    TargetHumans

    the P and E sites, respectively (PubMed:26593721). … Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (PubMed:26593721)

    Polypeptides: Elongation factor 2
  10. Target

    Trefoil factor 2

    go.drugbank.com/bio_entities/BE0004464
    TargetHumans

    Inhibits gastrointestinal motility and gastric acid secretion.

    Polypeptides: Trefoil factor 2