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Methylnaltrexone Opioid Antagonist Action Pathway
smpdb.ca/view/SMP0126308Drug actionMethylnaltrexone, also known as Relistor, is a μ-opioid antagonist. This drug is used in the treatment of opioid-induced constipation in palliative patients that are not responding to laxative therapy. This drug acts on the gastrointesti...
Drugs: ATP · Nitric Oxide · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Acetylcholine +2 moreNaloxegol Action Pathway
smpdb.ca/view/SMP0126335Drug actionNaloxegol, for PEGylated naloxol, is a peripherally-selective opioid antagonist used to treat opioid-induced constipation. Its pegylated structure allows for high selectivity for peripheral opioid receptors and lack of entry into the cen...
Drugs: ATP · Nitric Oxide · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Acetylcholine +2 moreNaldemedine Opioid Antagonist Action Pathway
smpdb.ca/view/SMP0126337Drug actionNaldemedine, also known as Symproic, is an opioid receptor antagonist. It is used to treat opioid-induced constipation (OIC). It is a modified form of Naltrexone to which a side chain has been added to increase molecular weight and polar...
Drugs: ATP · Nitric Oxide · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Acetylcholine +2 moreAlvimopan Opioid Antagonist Action Pathway
smpdb.ca/view/SMP0126339Drug actionAlvimopan, also known as Entereg, is an opioid antagonist used to reduce the healing time of the upper and lower GI tract following surgical procedures. It is a μ-opioid antagonist action only on the peripheral receptors and not on the o...
Drugs: ATP · Nitric Oxide · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Acetylcholine +2 moreMirtazapine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0174980Drug actionMirtazapine is a first-generation ethanolamine H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such...
Cyproheptadine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0174983Drug actionCyproheptadine is a first-generation ethanolamine H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions s...
Meclizine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0174987Drug actionMeclizine is an H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allergic...
Ketotifen H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0174991Drug actionKetotifen is an H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allergic...
Mequitazine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0174993Drug actionMequitazine is an H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allerg...
Cyclizine H1-Antihistamine Blood Vessel Constriction Action Pathway
smpdb.ca/view/SMP0174996Drug actionCyclizine is an H1 antihistamine and antiemetic drug used for the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo. H1-antihistamines interfere with the agonist action of histamine ...