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Displaying results 51 - 60 of 220 in total
  1. Pathway

    Benzocaine Action Pathway

    smpdb.ca/view/SMP0000392
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Benzocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Benzocaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Norepinephrine · Dopamine · Benzocaine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  2. Pathway

    Mepivacaine Action Pathway

    smpdb.ca/view/SMP0000399
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Mepivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Mepivacaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Norepinephrine · Mepivacaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  3. Pathway

    Prilocaine Action Pathway

    smpdb.ca/view/SMP0000401
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Prilocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Prilocaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Norepinephrine · Prilocaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  4. Pathway

    Ropivacaine Action Pathway

    smpdb.ca/view/SMP0000404
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Ropivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Ropivacaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Ropivacaine · Norepinephrine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  5. Pathway

    Citalopram Action Pathway

    smpdb.ca/view/SMP0000424
    Drug action

    It does so by competing for the same binding site as serotonin on the the sodium-dependent serotonin transporter (SLC6A4). … CREB-1 enters the nucleus and affects transcription of brain-derived neurotrophic factor (BDNF).

    Drugs: NADH · ATP · Citalopram · Norepinephrine · Dopamine · Potassium cation +5 more
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  6. Pathway

    Fluoxetine Action Pathway

    smpdb.ca/view/SMP0000426
    Drug action

    It does so by competing for the same binding site as serotonin on the the sodium-dependent serotonin transporter (SLC6A4). … CREB-1 enters the nucleus and affects transcription of brain-derived neurotrophic factor (BDNF).

    Drugs: NADH · ATP · Norepinephrine · Fluoxetine · Dopamine · Potassium cation +4 more
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  7. Pathway

    Nicotine Action Pathway

    smpdb.ca/view/SMP0000431
    Drug action

    This causes the channel to open and allow conductance of multiple cations including sodium, calcium, and potassium. … Binding opens the ion channel allowing influx of sodium, causing depolarization of the cell, which activates voltage-gated calcium channels.

    Drugs: NADH · ATP · Nicotine · Norepinephrine · Dopamine · Potassium cation +5 more
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  8. Pathway

    Codeine Action Pathway

    smpdb.ca/view/SMP0000405
    Drug action

    Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. … This results in hyperpolarization and reduced neuronal excitability.

    Drugs: NADH · ATP · Morphine · Codeine · Norepinephrine · Dopamine +5 more
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  9. Pathway

    Oxymorphone Action Pathway

    smpdb.ca/view/SMP0000412
    Drug action

    The binding of oxymorphone will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.

    Drugs: ATP · Norepinephrine · Dopamine · Oxymorphone · Potassium cation · Calcium
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter
  10. Pathway

    Carfentanil Action Pathway

    smpdb.ca/view/SMP0000414
    Drug action

    The binding of carfentanil will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.

    Drugs: ATP · Norepinephrine · Dopamine · Potassium cation · Calcium · Carfentanil
    Enzymes: Sodium channel subunit beta-1, Sodium-dependent serotonin transporter