Search
Insulin-like growth factor 1 receptor
go.drugbank.com/bio_entities/BE0000858TargetHumansReceptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. … Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor
Polypeptides: Insulin-like growth factor 1 receptorSynonyms: Insulin-like growth factor I receptorInsulin-like growth factor-binding protein 2
go.drugbank.com/bio_entities/BE0009659CarrierTargetHumansMultifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apopto...
Polypeptides: Insulin-like growth factor-binding protein 2Function: insulin-like growth factor I bindingInsulin-like growth factor-binding protein 5
go.drugbank.com/bio_entities/BE0009661CarrierHumansMultifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type spe...
Polypeptides: Insulin-like growth factor-binding protein 5Insulin-like growth factor-binding protein 6
go.drugbank.com/bio_entities/BE0009662CarrierHumansIGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Act...
Polypeptides: Insulin-like growth factor-binding protein 6Insulin-like growth factor-binding protein 3
go.drugbank.com/bio_entities/BE0000970TargetCarrierHumansInhibits the positive effect of humanin on insulin sensitivity (PubMed:19623253). Promotes testicular germ cell apoptosis (PubMed:19952275).
Polypeptides: Insulin-like growth factor-binding protein 3Insulin-like growth factor-binding protein 7
go.drugbank.com/bio_entities/BE0002126TargetHumansBinds IGF1 and IGF2 with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Acts as a ligand for CD93 to play a role in angiogenesis (PubMed:38218180)
Polypeptides: Insulin-like growth factor-binding protein 7Function: insulin-like growth factor bindingInsulin-like growth factor-binding protein complex acid labile subunit
go.drugbank.com/bio_entities/BE0009058TargetCarrierHumansInvolved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion
Polypeptides: Insulin-like growth factor-binding protein complex acid labile subunitFunction: insulin-like growth factor bindingPrimary Insulin-Like Growth Factor-1 Deficiency
go.drugbank.com/conditions/DBCOND0041585Synonyms: Primary insulin like growth factor-1 deficiency, Primary Insulin-Like Growth Factor-1 DeficiencyType 1 Diabetes Mellitus
go.drugbank.com/conditions/DBCOND0029465Drugs: Donislecel · Insulin degludec · Insulin detemir · Insulin glargine · Insulin glulisine · Insulin human +3 moreSynonyms: Insulin dependent diabetic, Insulin dependent diabetes melType 2 Diabetes
go.drugbank.com/conditions/DBCOND0030616Synonyms: Insulin resistant diabetes, Diabetes mellitus non insulin-dep