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Pasireotide
go.drugbank.com/drugs/DB06663ApprovedInvestigationalPasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease.
Categories: Pituitary and Hypothalamic Hormones and Analogues, Sex Hormones and InsulinsProducts: SIGNIFOR LAR POWDER AND SOLVENT FOR SUSPENSION FOR INJECTION 20MG, Signifor LAR 20mg powder and solvent for suspension for injectionGlimepiride
go.drugbank.com/drugs/DB00222ApprovedInvestigational[A177709] Glimepiride works by stimulating the secretion of insulin granules from pancreatic islet beta cells by blocking ATP-sensitive potassium channels (K<SUB>ATP</SUB> channels) and causing depolarization … The main effect of SUs is thought to be effective when residual pancreatic β-cells are present,[A177715] as they work by stimulating the release of insulin from the pancreatic beta cells and they are also
Mixtures: Pioglitazone and Glimepiride, Pioglitazone and GlimepirideCategories: Alimentary Tract and Metabolism, glimepiride and pioglitazoneMeperidine
go.drugbank.com/drugs/DB00454ApprovedInvestigationalA narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. … Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
Mixtures: Meperidine Hcl and Promethazine Hcl, Meperidine Hydrochloride and Promethazine HydrochlorideCategories: pethidine and antispasmodicsPerphenazine
go.drugbank.com/drugs/DB00850ApprovedInvestigationalAn antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine.
Mixtures: Perphenazine and Amitriptyline Hydrochloride, Perphenazine and Amitriptyline HydrochlorideProducts: Trilafon Conc 16mg/5ml, PMS Perphenazine Tab 16mgPyrithione
go.drugbank.com/drugs/DB06815ApprovedInvestigationalDue to low solubility, pyrithione zinc released from the topical formulations is deposited and retained relatively well onto the target skin surfaces [A27133]. … It mediates its action by increasing the cellular levels of copper, and damaging iron-sulfur clusters of proteins essential for fungal metabolism and growth [A27132].
Mixtures: Head and Shoulders Dual Sachets Full and Strong, Head and Shoulders Dual Sachets Full and StrongProducts: Skin-cap Spray-2mg/ml, Royal Oils by Head and Shoulders Moisture Boost 2in1Manidipine
go.drugbank.com/drugs/DB09238ApprovedInvestigationalWithdrawnIt is selective for vasculature and does not produce effects on the heart at clinically relevant dosages. … Manidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.
Mixtures: VIVACE 30/10MG TABLETTEN, VIVACE 30/10MG TABLETTENCategories: delapril and manidipine, ACE Inhibitors and Calcium Channel BlockersIntracellular Signalling Through PGD2 receptor and Prostaglandin D2
smpdb.ca/view/SMP0000343SignalingPGD is the major prostanoid released from human mast cells upon immunological challenge. Prostaglandin D2 (PGD2) can trigger asthmatic responses by acting as a cell-derived mediator in mice.
Metabolism and Physiological Effects of Indole Acetic Acid
smpdb.ca/view/SMP0123235MetabolicIndole acetic acid is an indole compound that is formed through gut microbial metabolism from dietary tryptophan through the indole-3-acetamide pathway . … Indole acetic acid is shown to cause inflammation and disrupt the electron transport chain and oxidative phosphorylation causing muscle atrophy.
Drugs: TryptophanMetabolism and Physiological Effects of Para-cresyl glucuronide
smpdb.ca/view/SMP0123299MetabolicMost of the p-cresol that is produced from the gut microbes then enters systemic circulation and is converted into P-cresyl sulphate by the liver. … Para-cresyl glucuronide (P-cresyl glucuronide) is a phenolic compound that is formed through gut microbial metabolism from dietary tyrosine and a glucuronidation reaction in liver hepatic cells.
Metabolism and Physiological Effects of 4-Hydroxyhippuric Acid
smpdb.ca/view/SMP0125537Metabolic; nuts such as cashews, almonds, pistachios; and dairy products such as yogurt, milk, and cheese. … Benzoic acid is present in many fruits, such as apricots, prunes, and berries; many vegetables such as mushrooms (fungus), snap peas, cucumbers, and radishes; spices such as cinnamon, cloves, and allspice