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Displaying results 601 - 610 of 3730 in total
  1. Target

    5-hydroxytryptamine receptor 1A

    go.drugbank.com/bio_entities/BE0000291
    TargetHumans

    Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed … G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:37935376, PubMed:37935377, PubMed:8138923, PubMed:8393041).

    Polypeptides: 5-hydroxytryptamine receptor 1ASynonyms: Serotonin receptor 1A
  2. Target

    5-hydroxytryptamine receptor 3A

    go.drugbank.com/bio_entities/BE0000311
    TargetHumans

    Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons

    Polypeptides: 5-hydroxytryptamine receptor 3ASynonyms: Serotonin receptor 3A, 5-hydroxytryptamine receptor 3
  3. Target

    Thyroid hormone receptor beta

    go.drugbank.com/bio_entities/BE0000315
    TargetHumans

    Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine

    Polypeptides: Thyroid hormone receptor betaSynonyms: Nuclear receptor subfamily 1 group A member 2
  4. Target

    Follicle-stimulating hormone receptor

    go.drugbank.com/bio_entities/BE0000387
    TargetHumans

    G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). … Also affects hepatic cholesterol metabolism by increasing serum total and low-density-lipoprotein cholesterol (LDL-C) by inhibiting the expression of LDL receptor (LDLR) (PubMed:26583582)

    Polypeptides: Follicle-stimulating hormone receptorSynonyms: Follitropin receptor
  5. Target

    Muscarinic acetylcholine receptor M4

    go.drugbank.com/bio_entities/BE0000405
    TargetHumans

    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action

    Polypeptides: Muscarinic acetylcholine receptor M4Function: G protein-coupled acetylcholine receptor activity
  6. Target

    Delta-type opioid receptor

    go.drugbank.com/bio_entities/BE0000420
    TargetHumans

    G protein-coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.

    Polypeptides: Delta-type opioid receptorFunction: G protein-coupled enkephalin receptor activity
  7. Target

    5-hydroxytryptamine receptor 2A

    go.drugbank.com/bio_entities/BE0000451
    TargetHumans

    Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538, PubMed:35084960). … G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895, PubMed:21645528, PubMed:22300836, PubMed:35084960, PubMed:38552625).

    Polypeptides: 5-hydroxytryptamine receptor 2ASynonyms: Serotonin receptor 2A
  8. Target

    Neurotensin receptor type 2

    go.drugbank.com/bio_entities/BE0000464
    TargetHumans

    Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system

    Polypeptides: Neurotensin receptor type 2Synonyms: Levocabastine-sensitive neurotensin receptor
  9. Target

    Melatonin receptor type 1A

    go.drugbank.com/bio_entities/BE0000515
    TargetHumans

    High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. … The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

    Polypeptides: Melatonin receptor type 1ASynonyms: Mel1a receptor
  10. Target

    Muscarinic acetylcholine receptor M2

    go.drugbank.com/bio_entities/BE0000560
    TargetHumans

    Muscarinic receptor for acetylcholine, a neurotransmitter found in the brain, neuromuscular junctions and the autonomic ganglia (PubMed:24256733, PubMed:3443095, PubMed:36690613). … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed

    Polypeptides: Muscarinic acetylcholine receptor M2