5-hydroxytryptamine receptor 3A

BE0000311ProteinHumansHTR3A

Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons. It is acted on by 40 drugs in DrugBank.

Gene name
HTR3A
UniProtKB entry
P46098Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
478 residues · 55,280 Da
Also known as
5-HT-3 · 5-HT3-A · 5-HT3A · 5-HT3R · 5-hydroxytryptamine receptor 3

Resolves to

Protein
UniProtP46098UniProt name5HT3A_HUMAN
Gene
HGNCHGNC:5297NCBI Gene3359GenBank681914GeneCardsHTR3A
Pharmacology
IUPHAR/GtoPdb373KEGGhsa:3359
Structure
PDB8AXDPDB8BL8PDB8BLA
Drugs

What you can answer from here — as of September 07, 2019

40DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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147+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 5-hydroxytryptamine receptor 3A, how selective are they, and which programs against it are still in active trials?

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