Search

Displaying results 611 - 620 of 688 in total
  1. Target

    Proteasome subunit alpha type-2

    go.drugbank.com/bio_entities/BE0003911
    TargetHumans

    Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)

    Synonyms: Multicatalytic endopeptidase complex subunit C3
  2. Target

    Proteasome subunit beta type-7

    go.drugbank.com/bio_entities/BE0003920
    TargetHumans

    Within the 20S core complex, PSMB7 displays a trypsin-like activity … Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins.

    Synonyms: Multicatalytic endopeptidase complex chain Z
  3. Drug

    Belzutifan

    go.drugbank.com/drugs/DB15463
    ApprovedInvestigational

    [L36105] Belzutifan inhibits the complexation of HIF-2α with another transcription factor, HIF-1β, a necessary step in its activation - by preventing the formation of this complex, belzutifan can slow

  4. Target

    Proteasome subunit alpha type-3

    go.drugbank.com/bio_entities/BE0003912
    TargetHumans

    Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).

    Synonyms: Multicatalytic endopeptidase complex subunit C8
  5. Target

    Serine/threonine-protein kinase mTOR

    go.drugbank.com/bio_entities/BE0002386
    TargetHumans

    The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). … The mTORC1 complex is inhibited in response to starvation and amino acid depletion (PubMed:12150925, PubMed:12150926, PubMed:24403073, PubMed:31695197).

    Synonyms: FKBP12-rapamycin complex-associated protein, FK506-binding protein 12-rapamycin complex-associated protein 1
  6. Target

    Proteasome subunit beta type-2

    go.drugbank.com/bio_entities/BE0002349
    TargetHumans

    Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. … This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)

    Synonyms: Multicatalytic endopeptidase complex subunit C7-I
  7. Drug

    alpha-Ketoisovalerate

    go.drugbank.com/drugs/DB04074
    Investigational

    Mixtures: ALFA KAPPA
  8. Target

    5-aminolevulinate synthase, non-specific, mitochondrial

    go.drugbank.com/bio_entities/BE0000409
    TargetHumans

    Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products

    Synonyms: Delta-ALA synthase 1
  9. Drug

    Desmeninol

    go.drugbank.com/drugs/DB15832
    Investigational

    Mixtures: ALFA KAPPA
  10. Target

    Phospholipid-transporting ATPase IA

    go.drugbank.com/bio_entities/BE0001001
    TargetHumans

    Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures … The flippase complex ATP8A1:CDC50A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the cell membrane (By similarity

    Synonyms: P4-ATPase flippase complex alpha subunit ATP8A1