Search

Displaying results 611 - 620 of 2256 in total
  1. Drug

    Butabarbital

    go.drugbank.com/drugs/DB00237
    ApprovedIllicitWithdrawn

    [A201977,L13613] Butabarbital is less commonly used in recent years, as more patients are typically prescribed benzodiazepines.

  2. Drug

    Levomilnacipran

    go.drugbank.com/drugs/DB08918
    ApprovedInvestigational

    Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake. Levomilnacipran is the more active 1S,2R-enantiomer in the ...

  3. Target

    Glycine receptor subunit beta

    go.drugbank.com/bio_entities/BE0000055
    TargetHumans

    Subunit of heteromeric glycine-gated chloride channels (PubMed:11929858, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:23238346, PubMed:25445488, PubMed:34473954, PubMed:8717357). Plays an important role in the down-regulatio...

    Polypeptides: Glycine receptor subunit betaSynonyms: Glycine receptor 58 kDa subunit
  4. Target

    Beta-1 adrenergic receptor

    go.drugbank.com/bio_entities/BE0000172
    TargetHumans

    Mediates the activation of Ras via binding with cAMP-dependent RAPGEF2 (PubMed:12391161). … G protein-coupled receptor for catecholamines that couples to G(s) proteins to activate adenylate cyclase and cAMP-dependent pathway (PubMed:10212248, PubMed:12391161, PubMed:15358775).

    Polypeptides: Beta-1 adrenergic receptorFunction: alpha-2A adrenergic receptor binding
  5. Target

    5-hydroxytryptamine receptor 1A

    go.drugbank.com/bio_entities/BE0000291
    TargetHumans

    Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed … G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:37935376, PubMed:37935377, PubMed:8138923, PubMed:8393041).

    Polypeptides: 5-hydroxytryptamine receptor 1ASynonyms: Serotonin receptor 1A
  6. Target

    5-hydroxytryptamine receptor 3A

    go.drugbank.com/bio_entities/BE0000311
    TargetHumans

    Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons

    Polypeptides: 5-hydroxytryptamine receptor 3ASynonyms: Serotonin receptor 3A, 5-hydroxytryptamine receptor 3
  7. Target

    Thyroid hormone receptor beta

    go.drugbank.com/bio_entities/BE0000315
    TargetHumans

    Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine

    Polypeptides: Thyroid hormone receptor betaSynonyms: Nuclear receptor subfamily 1 group A member 2
  8. Target

    Follicle-stimulating hormone receptor

    go.drugbank.com/bio_entities/BE0000387
    TargetHumans

    G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). … Also affects hepatic cholesterol metabolism by increasing serum total and low-density-lipoprotein cholesterol (LDL-C) by inhibiting the expression of LDL receptor (LDLR) (PubMed:26583582)

    Polypeptides: Follicle-stimulating hormone receptorSynonyms: Follitropin receptor
  9. Target

    Muscarinic acetylcholine receptor M4

    go.drugbank.com/bio_entities/BE0000405
    TargetHumans

    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action

    Polypeptides: Muscarinic acetylcholine receptor M4Function: G protein-coupled acetylcholine receptor activity
  10. Target

    Delta-type opioid receptor

    go.drugbank.com/bio_entities/BE0000420
    TargetHumans

    G protein-coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.

    Polypeptides: Delta-type opioid receptorFunction: G protein-coupled enkephalin receptor activity