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Displaying results 6311 - 6320 of 10000 in total
  1. Target

    Bifunctional epoxide hydrolase 2

    go.drugbank.com/bio_entities/BE0000950
    TargetEnzymeHumans

    Bifunctional enzyme (PubMed:12574510). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12574510, PubMed:12869654, PubMed:22798687). Plays a role in xenobiotic m...

    Polypeptides: Bifunctional epoxide hydrolase 2
  2. Target

    Metabotropic glutamate receptor 2

    go.drugbank.com/bio_entities/BE0000974
    TargetHumans

    Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (PubMed:37286794). Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inh...

    Polypeptides: Metabotropic glutamate receptor 2
  3. Target

    Fibroblast growth factor 2

    go.drugbank.com/bio_entities/BE0001015
    TargetHumans

    Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed:29501879)

    Polypeptides: Fibroblast growth factor 2Synonyms: FGF-2, HBGF-2
  4. Target

    Cyclin-dependent kinase 2

    go.drugbank.com/bio_entities/BE0001072
    TargetHumans

    Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis (PubMed:10499802, PubMed:10884347, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:1...

    Polypeptides: Cyclin-dependent kinase 2Synonyms: Cell division protein kinase 2
  5. Target

    Microtubule-associated protein 2

    go.drugbank.com/bio_entities/BE0001100
    TargetHumans

    The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules

    Polypeptides: Microtubule-associated protein 2Synonyms: MAP-2
  6. Target

    2-oxo-tetronate isomerase

    go.drugbank.com/bio_entities/BE0001368
    TargetEscherichia coli (strain K12)

    Catalyzes the isomerization of 2-oxo-tetronate to 3-oxo-tetronate.

    Polypeptides: 2-oxo-tetronate isomeraseSynonyms: 2-dehydrotetronate isomerase
  7. Target

    CDP-paratose 2-epimerase

    go.drugbank.com/bio_entities/BE0001635
    TargetSalmonella typhi

    Catalyzes the isomeration of CDP-paratose to CDP-tyvelose.

    Polypeptides: CDP-paratose 2-epimeraseSynonyms: CDP-tyvelose 2-epimerase
  8. Target

    (S)-2-haloacid dehalogenase

    go.drugbank.com/bio_entities/BE0001647
    TargetPseudomonas sp. (strain YL)

    Acts on acids of short chain lengths, C(2) to C(4), with inversion of configuration at C-2 (PubMed:7490277, PubMed:9614112). … Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids (PubMed:7490277, PubMed:9614112).

    Polypeptides: (S)-2-haloacid dehalogenaseSynonyms: L-2-haloacid dehalogenase, 2-haloalkanoic acid dehalogenase
  9. Target

    Beta-lactamase SHV-2

    go.drugbank.com/bio_entities/BE0002029
    TargetEscherichia coli

    This enzyme hydrolyzes cefotaxime, ceftazidime and other broad spectrum cephalosporins.

    Polypeptides: Beta-lactamase SHV-2
  10. Target

    Acyl-CoA thioesterase 2

    go.drugbank.com/bio_entities/BE0002038
    TargetEscherichia coli (strain K12)

    Thioesterase that has relatively broad substrate specificity, hydrolyzing primarily medium- and long-chain acyl-CoA substrates to free fatty acids and CoA (PubMed:1645722, PubMed:20547355, PubMed:24271180). Functions in the thioesterase-...

    Polypeptides: Acyl-CoA thioesterase 2