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Displaying results 661 - 670 of 2256 in total
  1. Target

    Leukemia inhibitory factor receptor

    go.drugbank.com/bio_entities/BE0013220
    TargetHumans

    Functions as a membrane-bound signal-transducing subunit either in complex with IL6ST/gp130 or as part of the ciliary neurotrophic factor receptor (CNTFR) complex composed by CNTFR, IL6ST/gp130 and LIFR … initiated either by binding directly to cytokines, such as OSM or LIF or CTF1, or through the binding of other cytokines, like CNTF, CLCF1 or the heterodimeric complex CRLF1-CLCF1 to the non-signaling receptor

    Polypeptides: Leukemia inhibitory factor receptorSynonyms: LIF receptor
  2. Target

    Nuclear receptor ROR-gamma

    go.drugbank.com/bio_entities/BE0013275
    TargetHumans

    Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence.

    Polypeptides: Nuclear receptor ROR-gammaSynonyms: Nuclear receptor RZR-gamma, RAR-related orphan receptor C
  3. Target

    Interleukin-17 receptor C

    go.drugbank.com/bio_entities/BE0017016
    TargetHumans

    Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). … Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971).

    Polypeptides: Interleukin-17 receptor CSynonyms: IL-17 receptor C, Interleukin-17 receptor homolog
  4. Target

    Interleukin-17 receptor E

    go.drugbank.com/bio_entities/BE0017393
    TargetHumans

    Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling.

    Polypeptides: Interleukin-17 receptor ESynonyms: IL-17 receptor E
  5. Target

    Lysophosphatidic acid receptor 3

    go.drugbank.com/bio_entities/BE0020529
    TargetHumans

    Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer.

    Polypeptides: Lysophosphatidic acid receptor 3Synonyms: LPA receptor 3, Lysophosphatidic acid receptor Edg-7
  6. Drug

    Loratadine

    go.drugbank.com/drugs/DB00455
    ApprovedInvestigational

    [A176435] A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations.

  7. Drug

    Caffeine

    go.drugbank.com/drugs/DB00201
    ApprovedInvestigational

    Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to Theophy...

  8. Drug

    Butabarbital

    go.drugbank.com/drugs/DB00237
    ApprovedIllicitWithdrawn

    [A201977,L13613] Butabarbital is less commonly used in recent years, as more patients are typically prescribed benzodiazepines.

  9. Drug

    Norethisterone

    go.drugbank.com/drugs/DB00717
    ApprovedInvestigational

    Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with levonorgestrel and ...

  10. Drug

    Mephenesin

    go.drugbank.com/drugs/DB13583
    ApprovedWithdrawn

    Mephenesin is a synthetic cresol glyceryl ether which produces transient muscle relaxation and paralysis via central nervous system depression [A32760]. It first entered use in the 1950s.