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Interleukin-31 receptor subunit alpha
go.drugbank.com/bio_entities/BE0011013TargetHumansIn addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1 (PubMed:15194700, PubMed:15627637). … Functions as a membrane-bound signal-transducing subunit of the IL31 receptor complex (heterodimer composed of OSMR and IL31RA) which binds IL31 (PubMed:15184896, PubMed:15194700, PubMed:15627637).
Polypeptides: Interleukin-31 receptor subunit alphaSynonyms: IL-31 receptor A, Gp130-like receptorVasoactive intestinal polypeptide receptor 1
go.drugbank.com/bio_entities/BE0013137TargetHumansG protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:35477937, PubMed:36385145, PubMed
Polypeptides: Vasoactive intestinal polypeptide receptor 1Synonyms: VPAC1 receptor, PACAP type II receptorGDNF family receptor alpha-1
go.drugbank.com/bio_entities/BE0013583TargetHumansGDNF-binding leads to autophosphorylation and activation of the RET receptor (PubMed:31535977)
Polypeptides: GDNF family receptor alpha-1Synonyms: GDNF receptor alpha-1, TGF-beta-related neurotrophic factor receptor 1Corticotropin-releasing hormone receptor 2
go.drugbank.com/bio_entities/BE0014244TargetHumansG protein-coupled receptor for CRH, UCN, UCN2 and UCN3 stress hormones, which plays a central role in whole body adaptation to stress (PubMed:11329063, PubMed:11416224, PubMed:20966082, PubMed:22689579
Polypeptides: Corticotropin-releasing hormone receptor 2Synonyms: Corticotropin-releasing factor receptor 2Interleukin-10 receptor subunit alpha
go.drugbank.com/bio_entities/BE0014391TargetHumansCell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.
Polypeptides: Interleukin-10 receptor subunit alphaSynonyms: IL-10 receptor subunit alpha, Interleukin-10 receptor subunit 1G protein-coupled receptor 68
go.drugbank.com/bio_entities/BE0014724TargetHumansThe receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (PubMed:12955148, PubMed:39753132). … Proton-sensing G protein-coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:12955148, PubMed:29677517, PubMed:32865988, PubMed
Polypeptides: G protein-coupled receptor 68Synonyms: G protein-coupled receptor 12A, Ovarian cancer G protein-coupled receptor 1G protein-coupled receptor 84
go.drugbank.com/bio_entities/BE0020007TargetHumansG protein-coupled receptor that responds endogenously to dietary fatty acids or nutrient, specifically medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. … In immune cells, functions as a pro-inflammatory receptor via 6-OAU and promotes the expression of pro-inflammatory mediators such as TNFalpha, IL-6 and IL-12B as well as stimulating chemotactic responses
Polypeptides: G protein-coupled receptor 84Synonyms: Inflammation-related G protein-coupled receptor EX33Pentobarbital
go.drugbank.com/drugs/DB00312ApprovedVet approvedA short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may ...
Sepetaprost
go.drugbank.com/drugs/DB12043InvestigationalSepetaprost has been used in trials studying the treatment of Open Angle-glaucoma, Ocular Hypertension, and Mild Open Angle-glaucoma (OAG).
Castor oil
go.drugbank.com/drugs/DB11113ApprovedNutraceuticalVet approvedCastor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (Ricinus communis L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of DB02955, which represents up to 90% o...