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Remdesivir
go.drugbank.com/drugs/DB14761ApprovedInvestigationalSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia … [L18438] Remdesivir was also approved by the European Commission on July 3, 2020.
Categories: Heterocyclic Compounds, 2-Ring, SARS-CoV-2 Nucleotide Analog RNA Polymerase InhibitorProducts: VEKLURY 100 MG İNFÜZYONLUK ÇÖZELTİ KONSANTRESİ İÇİN TOZ, 1 ADET, VEKLURY® LYOPHILIZED POWDER FOR IV INFUSION 100MG/VIAL2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
go.drugbank.com/bio_entities/BE0001661TargetEscherichia coli (strain K12)Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Polypeptides: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseSynonyms: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
go.drugbank.com/bio_entities/BE0001839TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Polypeptides: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseSynonyms: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
go.drugbank.com/bio_entities/BE0001574TargetShigella flexneriCatalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Polypeptides: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinaseSynonyms: 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
go.drugbank.com/bio_entities/BE0003931TargetHumansSynthesis and degradation of fructose 2,6-bisphosphate
Polypeptides: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4Synonyms: 6PF-2-K/Fru-2,6-P2ase 4, PFK/FBPase 4Dehydrogenase/reductase SDR family member 4-like 2
go.drugbank.com/bio_entities/BE0004192TargetHumansProbable oxidoreductase
Polypeptides: Dehydrogenase/reductase SDR family member 4-like 2Synonyms: Short chain dehydrogenase/reductase family 25C member 3Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
go.drugbank.com/bio_entities/BE0009517TargetHumansParticipates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:26774281, PubMed:9038203). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion ...
Polypeptides: Phosphatidylinositol 5-phosphate 4-kinase type-2 betaSynonyms: PtdIns(5)P-4-kinase isoform 2-beta, 1-phosphatidylinositol 5-phosphate 4-kinase 2-betaPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma
go.drugbank.com/bio_entities/BE0009518TargetHumansPhosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity.
Polypeptides: Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaSynonyms: PI(5)P 4-kinase type II gamma, Phosphatidylinositol 5-phosphate 4-kinase type II gammaMethoxyflurane
go.drugbank.com/drugs/DB01028ApprovedInvestigationalVet approvedWithdrawnIf so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: Penthrop 99,9%, 3 ml Flüssigkeit zur Herstellung eines Dampfs zur Inhalation, PENTHROX®Isavuconazole
go.drugbank.com/drugs/DB11633ApprovedInvestigationalIt is proposed that the intravenous and oral dosing can be used interchangeably [L1482], without the need for a repeat loading dose when transitioning from an IV to an oral formulation [A32026]. … intravenous formulation is cyclodextrin-free which gives isavuconazole an advantage over other azole antifungals that requires cyclodextrin for facilitating drug solubility; this is because cyclodextrin has a
Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP2B6 InducersProducts: CRESEMBA (100 MG HARD CAPSULES), CRESEMBA (POWDER FOR SOLUTION FOR CONCENTRATE FOR SOLUTION FOR INFUSION 200 MG/VIAL)