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Displaying results 6901 - 6910 of 10000 in total
  1. Target

    Sphingomyelin phosphodiesterase 4

    go.drugbank.com/bio_entities/BE0002300
    TargetHumans

    Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:16517606, PubMed:25180167). It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, an...

    Polypeptides: Sphingomyelin phosphodiesterase 4Synonyms: nSMase-3, Neutral sphingomyelinase 3
  2. Target

    Histone deacetylase 4

    go.drugbank.com/bio_entities/BE0003523
    TargetHumans

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation...

    Polypeptides: Histone deacetylase 4
  3. Target

    4-hydroxyphenylpyruvate dioxygenase

    go.drugbank.com/bio_entities/BE0004267
    TargetStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)

    Polypeptides: 4-hydroxyphenylpyruvate dioxygenaseFunction: 4-hydroxyphenylpyruvate dioxygenase activity
  4. Target

    P2X purinoceptor 4

    go.drugbank.com/bio_entities/BE0005793
    TargetHumans

    Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Also participates in basal T-cell activity without TCR/CD3 stimulation (By similarity).

    Polypeptides: P2X purinoceptor 4
  5. Target

    Melanocortin receptor 4

    go.drugbank.com/bio_entities/BE0009682
    TargetHumans

    In the PVN, also interacts with opsin 3/OPN3, which couples to G(i/o) proteins to inhibit MC4R-mediated cAMP signaling, thereby promoting food intake (PubMed:39951488).

    Polypeptides: Melanocortin receptor 4
  6. Target

    Platelet glycoprotein 4

    go.drugbank.com/bio_entities/BE0010538
    TargetTransporterHumans

    In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway

    Polypeptides: Platelet glycoprotein 4Synonyms: PAS-4
  7. Indication

    Poliomyelitis caused by poliovirus type 2

    go.drugbank.com/conditions/DBCOND0093720
    Drugs: Poliovirus type 2 antigen (formaldehyde inactivated)
    Synonyms: Poliomyelitis caused by poliovirus type 2
  8. Indication

    Metastatic Her-2 Positive Gastric Cancer

    go.drugbank.com/conditions/DBCOND0146827
    Drugs: Trastuzumab deruxtecan
    Synonyms: Metastatic Her-2 Positive Gastric Cancer
  9. Target

    Monocarboxylate transporter 4

    go.drugbank.com/bio_entities/BE0000449
    TargetTransporterHumans

    Proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate (PubMed:11101640, PubMed:23935841, PubMed:31719150). Plays a predominant role in L-lactate efflux from highly glycolytic cells (By similarity)

    Polypeptides: Monocarboxylate transporter 4Synonyms: MCT 4, Solute carrier family 16 member 3
  10. Target

    Carbonic anhydrase 4

    go.drugbank.com/bio_entities/BE0000535
    TargetEnzymeHumans

    Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH (PubMed:15563508, PubMed:16686544, PubMed:16807956, PubMed:17127057, PubMed:1731404...

    Polypeptides: Carbonic anhydrase 4