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Displaying results 61 - 70 of 185 in total
  1. Target

    Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

    go.drugbank.com/bio_entities/BE0003558
    TargetHumans

    Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148) … Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:10725373, PubMed:10906126, PubMed:11050148, PubMed:16330539).

    Polypeptides: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11ASynonyms: cAMP and cGMP phosphodiesterase 11A
  2. Target

    Ankyrin repeat and protein kinase domain-containing protein 1

    go.drugbank.com/bio_entities/BE0009411
    TargetHumans

    Polypeptides: Ankyrin repeat and protein kinase domain-containing protein 1
  3. Target

    Pendrin

    go.drugbank.com/bio_entities/BE0009874
    TransporterHumans

    Mediates electroneutral chloride-bicarbonate, chloride-iodide and chloride-formate exchange with 1:1 stoichiometry (PubMed:10644529, PubMed:15155570, PubMed:24051746, PubMed:35601831). … Sodium-independent transporter of chloride and iodide (PubMed:10192399, PubMed:11932316, PubMed:12107249, PubMed:16684826, PubMed:24051746).

    Synonyms: Sodium-independent chloride/iodide transporterFunction: chloride transmembrane transporter activity
  4. Target

    Solute carrier family 12 member 4

    go.drugbank.com/bio_entities/BE0000601
    TargetTransporterHumans

    Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:35759661). May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912).

    Synonyms: Electroneutral potassium-chloride cotransporter 1
  5. Target

    Solute carrier family 12 member 3

    go.drugbank.com/bio_entities/BE0000419
    TargetTransporterHumans

    Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules (PubMed:18270262, PubMed:21613606, PubMed:22009145 … Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2 (By similarity).

    Synonyms: Thiazide-sensitive sodium-chloride cotransporter
  6. Target

    cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

    go.drugbank.com/bio_entities/BE0000631
    TargetHumans

    May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition (PubMed:27058447) … Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10373451, PubMed:10393245, PubMed:17389385, PubMed:27058447).

    Polypeptides: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
  7. Target

    2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2

    go.drugbank.com/bio_entities/BE0002203
    TargetHumans

    Polypeptides: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2
  8. Target

    TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

    go.drugbank.com/bio_entities/BE0005824
    TargetHumans

    Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530 … Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:11847341, PubMed:29229647).

    Polypeptides: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
  9. Target

    Solute carrier family 12 member 5

    go.drugbank.com/bio_entities/BE0000047
    TargetTransporterHumans

    Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (PubMed:12106695). … As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization

    Synonyms: Electroneutral potassium-chloride cotransporter 2
  10. Target

    General transcription and DNA repair factor IIH helicase/translocase subunit XPB

    go.drugbank.com/bio_entities/BE0012820
    TargetHumans

    The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape (PubMed:10024882). … In transcription pre-initiation complexes induces and propagates a DNA twist to open DNA (PubMed:27193682, PubMed:33902107).

    Polypeptides: General transcription and DNA repair factor IIH helicase/translocase subunit XPB