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Displaying results 61 - 70 of 178 in total
  1. Target

    RalA-binding protein 1

    go.drugbank.com/bio_entities/BE0004770
    TransporterHumans

    As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10910768, PubMed:12775724).

  2. Target

    Alpha adrenergic receptor

    go.drugbank.com/bio_entities/BE0004888
    TargetHumans

    Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release (PubMed:2164221). … Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release (PubMed:2842764).

  3. Target

    Solute carrier family 2, facilitated glucose transporter member 8

    go.drugbank.com/bio_entities/BE0005219
    TransporterHumans

    Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (By similarity).

  4. Target

    Ephrin type-A receptor 5

    go.drugbank.com/bio_entities/BE0005587
    TargetHumans

    In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity

  5. Target

    Sulfonylurea receptor 1, Kir6.2

    go.drugbank.com/bio_entities/BE0008670
    TargetHumans

    Regulator subunit of pancreatic ATP-sensitive potassium channel (KATP), playing a major role in the regulation of insulin release.

  6. Target

    Heterogeneous nuclear ribonucleoprotein H

    go.drugbank.com/bio_entities/BE0008961
    TargetHumans

    Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG)

  7. Target

    Splicing factor, proline- and glutamine-rich

    go.drugbank.com/bio_entities/BE0008965
    TargetHumans

    Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF1-stimulated transcriptional activity.

  8. Target

    Eukaryotic translation initiation factor 6

    go.drugbank.com/bio_entities/BE0008972
    TargetHumans

    Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. … In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or

  9. Target

    Tyrosine-protein kinase Blk

    go.drugbank.com/bio_entities/BE0009413
    TargetHumans

    In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PubMed:19667185).

  10. Target

    Tyrosine-protein kinase Fer

    go.drugbank.com/bio_entities/BE0009443
    TargetHumans

    Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase.