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Displaying results 731 - 740 of 2256 in total
  1. Drug

    Empagliflozin

    go.drugbank.com/drugs/DB09038
    ApprovedInvestigational

    [A203501] As the most recently approved of the "flozin" drugs, empagliflozin carries the highest selectivity for SGLT2 over SGLT1 (approximately 2700-fold).

  2. Target

    Endothelin receptor type B

    go.drugbank.com/bio_entities/BE0000043
    TargetHumans

    Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

    Polypeptides: Endothelin receptor type BSynonyms: Endothelin receptor non-selective type
  3. Target

    Muscarinic acetylcholine receptor M3

    go.drugbank.com/bio_entities/BE0000045
    TargetHumans

    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action

    Polypeptides: Muscarinic acetylcholine receptor M3
  4. Target

    Muscarinic acetylcholine receptor M1

    go.drugbank.com/bio_entities/BE0000092
    TargetHumans

    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action

    Polypeptides: Muscarinic acetylcholine receptor M1Function: G protein-coupled acetylcholine receptor activity
  5. Target

    Cysteinyl leukotriene receptor 2

    go.drugbank.com/bio_entities/BE0000099
    TargetHumans

    Receptor for cysteinyl leukotrienes. The response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system.

    Polypeptides: Cysteinyl leukotriene receptor 2Synonyms: G protein-coupled receptor HG57, G protein-coupled receptor GPCR21
  6. Target

    Lutropin-choriogonadotropic hormone receptor

    go.drugbank.com/bio_entities/BE0000134
    TargetHumans

    Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099)

    Polypeptides: Lutropin-choriogonadotropic hormone receptorSynonyms: Luteinizing hormone receptor
  7. Target

    Retinoic acid receptor gamma

    go.drugbank.com/bio_entities/BE0000144
    TargetHumans

    Receptor for retinoic acid.

    Polypeptides: Retinoic acid receptor gammaSynonyms: Nuclear receptor subfamily 1 group B member 3
  8. Target

    Toll-like receptor 7

    go.drugbank.com/bio_entities/BE0000155
    TargetHumans

    Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:14976261, PubMed:32433612).

    Polypeptides: Toll-like receptor 7
  9. Target

    Gonadotropin-releasing hormone receptor

    go.drugbank.com/bio_entities/BE0000203
    TargetHumans

    This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling … Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH

    Polypeptides: Gonadotropin-releasing hormone receptorSynonyms: GnRH receptor
  10. Target

    Activin receptor type-1

    go.drugbank.com/bio_entities/BE0000264
    TargetHumans

    May promote the expression of HAMP, potentially via its interaction with BMP6 (By similarity) … As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B (PubMed:17911401).

    Polypeptides: Activin receptor type-1Synonyms: Activin receptor type I, Activin receptor-like kinase 2