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C-C chemokine receptor type 8
go.drugbank.com/bio_entities/BE0013343TargetHumansG protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18 (PubMed:23999500, PubMed:35041514). Regulates monocyte and eosinophil chemotaxis.
Polypeptides: C-C chemokine receptor type 8Synonyms: Chemokine receptor-like 1, CC chemokine receptor CHEMR1Oncostatin-M-specific receptor subunit beta
go.drugbank.com/bio_entities/BE0018846TargetHumansFunctions as a shared membrane-bound signal-transducing subunit in two distinct receptor complexes, the type II OSM receptor (heterodimer composed of OSMR and IL6ST) and the IL31 receptor complex (heterodimer … In addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1 (PubMed:15627637)
Polypeptides: Oncostatin-M-specific receptor subunit betaSynonyms: IL-31 receptor subunit beta, Interleukin-31 receptor subunit betaTaste receptor type 2 member 4
go.drugbank.com/bio_entities/BE0020472TargetHumansGustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.
Polypeptides: Taste receptor type 2 member 4Function: bitter taste receptor activityShort transient receptor potential channel 6
go.drugbank.com/bio_entities/BE0020965TargetHumansMediates calcium entry following G(q)-coupled receptor or receptor tyrosine kinase activation, which triggers phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositides and production of diacylglycerol
Polypeptides: Short transient receptor potential channel 6Synonyms: Transient receptor protein 6Neuropeptide Y receptor type 4-2
go.drugbank.com/bio_entities/BE0024014TargetHumansG protein-coupled receptor for PPY/pancreatic polypeptide/PP, NPY/neuropeptide Y and PYY/peptide YY that is negatively coupled to cAMP.
Polypeptides: Neuropeptide Y receptor type 4-2Function: pancreatic polypeptide receptor activityT cell receptor gamma variable 9
go.drugbank.com/bio_entities/BE0025222TargetHumansV region of the variable domain of T cell receptor (TR) gamma chain that participates in the antigen recognition (PubMed:24600447).
Polypeptides: T cell receptor gamma variable 9Vascular endothelial growth factor receptor 3
go.drugbank.com/bio_entities/BE0000023TargetHumansThe secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. … Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular
Polypeptides: Vascular endothelial growth factor receptor 3Synonyms: Tyrosine-protein kinase receptor FLT4Receptor-type tyrosine-protein kinase FLT3
go.drugbank.com/bio_entities/BE0000147TargetHumansTyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells.
Polypeptides: Receptor-type tyrosine-protein kinase FLT3Synonyms: FL cytokine receptorSigma non-opioid intracellular receptor 1
go.drugbank.com/bio_entities/BE0000290TargetHumansFunctions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the...
Polypeptides: Sigma non-opioid intracellular receptor 1Synonyms: Sigma 1-type opioid receptor, Sigma non-opioid intracellular receptor 1Vascular endothelial growth factor receptor 2
go.drugbank.com/bio_entities/BE0000369TargetHumansTyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD.
Polypeptides: Vascular endothelial growth factor receptor 2Synonyms: Kinase insert domain receptor, Protein-tyrosine kinase receptor flk-1