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Displaying results 751 - 760 of 10000 in total
  1. Drug

    Hydrocortisone

    go.drugbank.com/drugs/DB00741
    ApprovedInvestigationalVet approved

    Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex.[A188387] Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions. … [A188420] Hydrocortisone was granted FDA approval on 5 August 1952.[L10574]

    Synonyms: Kendall's compound F, Reichstein's substance MInternational brands: Polcort H, Preparation H Hydrocortisone Cream
  2. Target

    Glutamate mutase sigma subunit

    go.drugbank.com/bio_entities/BE0001771
    TargetClostridium tetanomorphum

    Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).

    Synonyms: Glutamate mutase S chain
  3. Target

    Anamorsin

    go.drugbank.com/bio_entities/BE0015312
    TargetHumans

    Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. … Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2.

    Synonyms: Fe-S cluster assembly protein DRE2 homolog
  4. Pathway

    nAchR Smooth Muscle Contraction

    smpdb.ca/view/SMP0126643
    Physiological

    Acetylcholine released from neuromuscular neurons activates nicotinic acetylcholine receptors (nAchR) on smooth muscle membranes.

    Drugs: Calcium · Magnesium cation · Acetylcholine
  5. Drug

    Terbinafine

    go.drugbank.com/drugs/DB00857
    ApprovedInvestigationalVet approved

    Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. … [A1279] Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epoxidase), an enzyme that is part of the fungal cell wall

    Synonyms: (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine, (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamineMixtures: Fluconazole 4% / Ibuprofen 2% / Itraconazole 1% / Terbinafine HCl 4%, Ciclopirox 8% / Fluconazole 1% / Terbinafine HCl 1%
  6. Drug

    Metronidazole

    go.drugbank.com/drugs/DB00916
    ApprovedInvestigational

    Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. … [L3754] It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.

    Synonyms: 1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole, 1-(β-ethylol)-2-methyl-5-nitro-3-azapyrroleInternational brands: Tricowas B
  7. Target

    Cytochrome P450 2C19

    go.drugbank.com/bio_entities/BE0003536
    EnzymeTargetHumans

    Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). … Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine

    Synonyms: (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase
  8. Drug

    Clobetasol propionate

    go.drugbank.com/drugs/DB01013
    ApprovedInvestigational

    Clobetasol propionate is a prednisolone derivative with higher specificity for glucocorticoid receptors than mineralocorticoid receptors.

    Synonyms: Clobetasol propionate E, 21-chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-propionateInternational brands: Embeline E
  9. Target

    Peptidyl-prolyl cis-trans isomerase B

    go.drugbank.com/bio_entities/BE0002332
    TargetHumans

    Peptidyl-prolyl cis-trans isomerase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding

    Synonyms: S-cyclophilin
  10. Target

    Purine nucleoside phosphorylase

    go.drugbank.com/bio_entities/BE0003172
    TargetPlasmodium falciparum (isolate 3D7)

    Also catalyzes the phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine; MTI is produced by adenosine deaminase (ADA)-mediated breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product

    Synonyms: S-methyl-5'-thioinosine phosphorylase