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Displaying results 771 - 780 of 10000 in total
  1. Drug

    Aldesleukin

    go.drugbank.com/drugs/DB00041
    ApprovedInvestigational

    Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. … Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2.

    Synonyms: 125-L-Serine-2-133-interleukin 2, 125-L-serine-2-133-interleukin 2 (human reduced)Categories: Cytochrome P-450 CYP2E1 Inhibitors, Cytochrome P-450 CYP3A Inhibitors
  2. Drug

    Reviparin

    go.drugbank.com/drugs/DB09259
    Approved

    Reviparin is a low molecular weight heparin which seems to have a better safety profile than unfractionated heparin. … Reviparin has a molecular weight of 3.9 kDa.[A32021] It was developed by Abbott laboratories and in 2009, reviparin presented an orphan drug designation by the FDA.[L1469]

    Products: CLIVARIN 5726 IE A XA/ML, CLIVARODI 17178 A XA/ML
  3. Drug

    Ferric carboxymaltose

    go.drugbank.com/drugs/DB08917
    ApprovedInvestigational

    Ferric carboxymaltose is an iron replacement product and, chemically, an iron-carbohydrate complex. It was FDA approved on July 25, 2013.

    Categories: Compounds used in a research, industrial, or household settingProducts: Ferinject 50 mg Eisen/ml Injektionslösung oder Konzentrat zur Herstellung einer Infusionslösung, FERINJECT®
  4. Target

    DNA gyrase subunit A

    go.drugbank.com/bio_entities/BE0000366
    TargetHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

    A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state.

    Polypeptides: DNA gyrase subunit A
  5. Target

    Leukotriene A-4 hydrolase

    go.drugbank.com/bio_entities/BE0001680
    TargetHumans

    Can utilize LTA5 less effectively as a substrate than LTA4, and produce LTB5 (PubMed:2996528). … addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a

    Polypeptides: Leukotriene A-4 hydrolaseSynonyms: Leukotriene A(4) hydrolase
  6. Target

    Acetyl-coenzyme A synthetase

    go.drugbank.com/bio_entities/BE0001916
    TargetSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

    Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate.

    Polypeptides: Acetyl-coenzyme A synthetase
  7. Target

    Nucleoside diphosphate kinase A

    go.drugbank.com/bio_entities/BE0003106
    TargetEnzymeHumans

    Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore … May also function as a Mg(2+)-dependent 3'-5' DNA exonuclease, excising nucleotides from 3' single-stranded DNA or DNA with 3' single strand overhangs, suggesting a role in DNA nucleolytic processing (

    Polypeptides: Nucleoside diphosphate kinase ASynonyms: NDPK A, NDP kinase A
  8. Target

    Stringent starvation protein A

    go.drugbank.com/bio_entities/BE0003260
    TargetYersinia pestis

    Polypeptides: Stringent starvation protein ASynonyms: Putative stringent starvation protein A, Regulator of transcription stringent starvation protein A
  9. Target

    Poly(A) polymerase alpha

    go.drugbank.com/bio_entities/BE0004515
    TargetHumans

    May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus … Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites.

    Polypeptides: Poly(A) polymerase alpha
  10. Target

    DNA gyrase subunit A

    go.drugbank.com/bio_entities/BE0008382
    TargetEscherichia coli (strain K12)

    A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state (PubMed:12051842, PubMed:18642932,

    Polypeptides: DNA gyrase subunit A