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Ephrin type-A receptor 6
go.drugbank.com/bio_entities/BE0009439TargetHumansReceptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity)
Polypeptides: Ephrin type-A receptor 6Sphingosine 1-phosphate receptor 3
go.drugbank.com/bio_entities/BE0009881TargetHumansReceptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues.
Polypeptides: Sphingosine 1-phosphate receptor 3Synonyms: S1P receptor 3, S1P receptor Edg-3Interleukin-6 receptor subunit beta
go.drugbank.com/bio_entities/BE0010013TargetHumansFunctions as a shared signal-transducing subunit not only for IL6 but also for other cytokine receptor complexes, including IL6, LIF, OSM, CNTF, IL11, CTF1, BSF3, MT-RNR2/humanin, CLCF1 and the heterodimeric … Binding of cytokines, such as IL6 or IL11 to the alpha-chains of their specific cell surface receptor triggers homodimerization of IL6ST/gp130 (PubMed:19915009, PubMed:2261637, PubMed:23294003, PubMed:
Polypeptides: Interleukin-6 receptor subunit betaSynonyms: IL-6 receptor subunit beta, Oncostatin-M receptor subunit alphaFree fatty acid receptor 2
go.drugbank.com/bio_entities/BE0010131TargetHumansExhibits a SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016) … G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis
Polypeptides: Free fatty acid receptor 2Synonyms: G protein-coupled receptor 43Uracil nucleotide/cysteinyl leukotriene receptor
go.drugbank.com/bio_entities/BE0010169TargetHumansDual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase.
Polypeptides: Uracil nucleotide/cysteinyl leukotriene receptorSynonyms: P2Y-like receptor, UDP/CysLT receptorPlatelet-derived growth factor receptor
go.drugbank.com/bio_entities/BE0010249TargetHumansReceptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor … Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor
Polypeptides: Platelet-derived growth factor receptor alpha, Platelet-derived growth factor receptor betaSynonyms: Alpha platelet-derived growth factor receptor, Platelet-derived growth factor receptor 2Aryl hydrocarbon receptor nuclear translocator
go.drugbank.com/bio_entities/BE0010296TargetHumansForms heterodimers with the aryl hydrocarbon receptor (AHR) to mediate the transcriptional response to xenobiotics by binding xenobiotic response elements (XREs) or dioxin response elements (DREs) in target
Polypeptides: Aryl hydrocarbon receptor nuclear translocatorSynonyms: Dioxin receptor, nuclear translocatorInterleukin-1 receptor accessory protein
go.drugbank.com/bio_entities/BE0010488TargetHumansSignaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. … The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system.
Polypeptides: Interleukin-1 receptor accessory proteinSynonyms: Interleukin-1 receptor 3, IL-1 receptor accessory proteinInterleukin-15 receptor subunit alpha
go.drugbank.com/bio_entities/BE0010620TargetHumansHigh-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity).
Polypeptides: Interleukin-15 receptor subunit alphaSynonyms: IL-15 receptor subunit alphaGDNF family receptor alpha-3
go.drugbank.com/bio_entities/BE0011826TargetHumansARTN-binding leads to autophosphorylation and activation of the RET receptor (PubMed:31535977, PubMed:9883723) … Receptor for artemin (ARTN), a growth factor that supports the survival of sensory and sympathetic peripheral neurons (PubMed:31535977, PubMed:9883723).
Polypeptides: GDNF family receptor alpha-3Synonyms: GDNF receptor alpha-3