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Acid-sensing ion channel 1
go.drugbank.com/bio_entities/BE0000353TargetTransporterHumansForms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and … Regulates more or less directly intracellular calcium concentration and CaMKII phosphorylation, and thereby the density of dendritic spines.
Polypeptides: Acid-sensing ion channel 1Acid-sensing ion channel 2
go.drugbank.com/bio_entities/BE0000678TargetHumansBy forming heterotrimeric channels with ASIC1, could contribute to synaptic plasticity, learning, and memory. … Additionally, as acid sensors at nerve terminals, plays a role in mechanosensation and phototransduction (By similarity)
Polypeptides: Acid-sensing ion channel 2Free fatty acid receptor 1
go.drugbank.com/bio_entities/BE0000688TargetHumansG protein-coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. … Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1).
Polypeptides: Free fatty acid receptor 1Excitatory amino acid transporter 2
go.drugbank.com/bio_entities/BE0000884TargetTransporterHumansMediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). … Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:14506254, PubMed:15265858, PubMed:26690923, PubMed:7521911).
Polypeptides: Excitatory amino acid transporter 2Fatty acid-binding protein, adipocyte
go.drugbank.com/bio_entities/BE0001194CarrierTargetHumansBinds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus
Polypeptides: Fatty acid-binding protein, adipocyteSynonyms: Fatty acid-binding protein 4, Adipocyte-type fatty acid-binding proteinCyclopropane mycolic acid synthase 2
go.drugbank.com/bio_entities/BE0001211TargetMycobacterium tuberculosisacid. … Catalyzes the formation of trans cyclopropanated ketomycolate or methoxymycolate through the conversion of a double bond to a cyclopropane ring at the proximal position of an oxygenated mycolic acid via
Polypeptides: Cyclopropane mycolic acid synthase 2Synonyms: Cyclopropane fatty acid synthase, Mycolic acid methyltransferaseFatty acid metabolism regulator protein
go.drugbank.com/bio_entities/BE0001383TargetShigella flexneriMultifunctional regulator of fatty acid metabolism.
Polypeptides: Fatty acid metabolism regulator proteinExcitatory amino acid transporter 4
go.drugbank.com/bio_entities/BE0002270TargetHumansMediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:7791878). … Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:26690923, PubMed:7791878).
Polypeptides: Excitatory amino acid transporter 4Cyclopropane mycolic acid synthase MmaA2
go.drugbank.com/bio_entities/BE0002512TargetMycobacterium tuberculosisCatalyzes the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. … Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence.
Polypeptides: Cyclopropane mycolic acid synthase MmaA2Synonyms: Mycolic acid methyltransferaseNogalonic acid methyl ester cyclase
go.drugbank.com/bio_entities/BE0003204TargetStreptomyces nogalaterCatalyzes the formation of nogalaviketone from nogalonic acid methyl ester (NAME), the last ring-closure step in the biosynthesis of nogalamycin.
Polypeptides: Nogalonic acid methyl ester cyclase