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Displaying results 71 - 80 of 93 in total
  1. Target

    Recombining binding protein suppressor of hairless

    go.drugbank.com/bio_entities/BE0014074
    TargetHumans

    Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380).

  2. Target

    DNA repair nuclease/redox regulator APEX1

    go.drugbank.com/bio_entities/BE0002414
    TargetHumans

    Operates at switch sites of immunoglobulin (Ig) constant regions where it mediates Ig isotype class switch recombination. Processes AP sites induced by successive action of AICDA and UNG.

  3. Target

    Tyrosine-protein kinase Blk

    go.drugbank.com/bio_entities/BE0009413
    TargetHumans

    Also phosphorylates the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C (PubMed:8756631). … Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis

  4. Target

    Poly [ADP-ribose] polymerases

    go.drugbank.com/bio_entities/BE0010108
    TargetHumans

    Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (By similarity). … Suppresses G-quadruplex (G4) structures in response to DNA damage (PubMed:28447610).

  5. Target

    Protein mono-ADP-ribosyltransferase PARP3

    go.drugbank.com/bio_entities/BE0004049
    TargetHumans

    Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin (By similarity). … Suppresses G-quadruplex (G4) structures in response to DNA damage (PubMed:28447610).

  6. Target

    Tyrosine-protein phosphatase non-receptor type substrate 1

    go.drugbank.com/bio_entities/BE0010650
    TargetHumans

    Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane.

  7. Target

    Tumor necrosis factor receptor

    go.drugbank.com/bio_entities/BE0010282
    TargetHumans

    Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity)

  8. Target

    Alpha-enolase

    go.drugbank.com/bio_entities/BE0005807
    TargetHumans

    Stimulates immunoglobulin production (PubMed:1369209)

  9. Target

    TNF receptor-associated factor 6

    go.drugbank.com/bio_entities/BE0021309
    TargetHumans

    Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity).

  10. Target

    Serine-protein kinase ATM

    go.drugbank.com/bio_entities/BE0004874
    TargetHumans

    Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen … After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility