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Triflupromazine - Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126610Drug actionTriflupromazine is a member of a class of drugs called phenothiazines, which are dopamine D1/D2 receptor antagonists. Triflupromazine is used particularly to control violent behavior during acute episodes of psychotic disorders. It can a...
Rotigotine Dopamine Agonist Action Pathway
smpdb.ca/view/SMP0126641Drug actionRotigotine is an agonist at all 5 dopamine receptor subtypes (D1-D5) but binds to the D3 receptor with the highest affinity. It is delivered continuously through the skin (transdermal) using a silicone-based patch that is replaced every ...
Lisuride Dopamine Agonist Action Pathway
smpdb.ca/view/SMP0126654Drug actionLisuride is an anti-Parkinson drug chemically related to the dopaminergic ergoline Parkinson's drugs. Lisuride binds to the 5-HT(1A) and 5-HT(2A/2C) receptors. Lisuride is an ergot derivative that acts as an agonist at dopamine D2 recept...
Olanzapine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126805Drug actionlanzapine is an atypical (second-generation) antipsychotic that exerts its action primarily on dopamine and serotonin receptors. It works on dopamine D2 receptors in the mesolimbic pathway as an antagonist, blocking dopamine from potenti...
Methysergide Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126851Drug actionMethysergide is an ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle. Methysergide is a semisynthetic ergot alkaloid ergometrine...
Clozapine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126963Drug actionClozapine is an antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Clozapine is available as oral tablets. Clozapine is part of a group of drugs known as second-generation...
DOPA-Responsive Dystonia
smpdb.ca/view/SMP0000486DiseaseDOPA-Responsive Dystonia is a condition in which the muscles contract, experience tremors and uncontrolled movements (dystonia). Some cases are mild, while others can be severe. The beginning signs of this condition are dystonia in the l...
Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency
smpdb.ca/view/SMP0000487DiseaseHyperphenylalaninemia is the high presence of phenylalanine in the system/blood caused by a genetic mutation. In this case a missense error in the gene which encodes GTP cyclohydrolase. Consequently, this form of hyperphenylalaninemia is...
Hyperphenylalaninemia Due to DHPR-Deficiency
smpdb.ca/view/SMP0000489DiseaseHyperphenylalaninemia due to dihydropteridine reductase deficiency (DHPR) is the high presence of phenylalanine in the system/blood caused by a genetic mutation. More specificially, mutations in the QDPR gene are the root cause of the co...
Sepiapterin Reductase Deficiency
smpdb.ca/view/SMP0000491DiseaseSepiapterin reductase deficiency results from a metabolic disorder; namely, the underproduction of Sepiapterin. The cause of this underproduction is an autosomal recessive genetic mutation in the SPR gene. This gene is responsible for Se...