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Displaying results 71 - 80 of 178 in total
  1. Target

    Serine/threonine-protein kinase pim-3

    go.drugbank.com/bio_entities/BE0009516
    TargetHumans

    Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6.

  2. Target

    Voltage-gated sodium channel alpha subunit

    go.drugbank.com/bio_entities/BE0009738
    TargetHumans

    For instance, it controls the release of serotonin/5-hydroxytryptamine by enterochromaffin cells and is required for both glucagon- and glucose-induced insulin secretion in pancreatic endocrine cells (

  3. Target

    Voltage-gated Potassium Channels

    go.drugbank.com/bio_entities/BE0009847
    Target

    May play a role in regulating the secretion of insulin in normal pancreatic islets … Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member.

  4. Target

    Zinc transporter ZIP5

    go.drugbank.com/bio_entities/BE0009888
    TransporterHumans

    Also may regulate glucose-stimulated insulin secretion (GSIS) in islets primarily through the zinc-activated SIRT1-PPARGC1A axis (By similarity).

  5. Target

    Proton-coupled zinc antiporter SLC30A5

    go.drugbank.com/bio_entities/BE0009898
    TransporterHumans

    Through the transport of zinc into secretory granules of pancreatic beta-cells, plays an important role in the storage and secretion of insulin (PubMed:11904301)

  6. Target

    Inhibin beta A chain

    go.drugbank.com/bio_entities/BE0010139
    TargetHumans

    involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin

  7. Target

    Phosphatidylinositol 3-kinase

    go.drugbank.com/bio_entities/BE0010298
    TargetHumans

    Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. … During insulin stimulation, it also binds to IRS-1

  8. Target

    Mitogen-activated protein kinase kinase kinase 8

    go.drugbank.com/bio_entities/BE0010492
    TargetHumans

    In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle.

  9. Target

    Tumor necrosis factor receptor superfamily member 16

    go.drugbank.com/bio_entities/BE0010540
    TargetHumans

    to the regulation of insulin-dependent glucose uptake (By similarity). … Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes

  10. Target

    Beta-arrestin-2

    go.drugbank.com/bio_entities/BE0013128
    TargetHumans

    Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR.