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Anamorsin
go.drugbank.com/bio_entities/BE0015312TargetHumansComponent of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. … Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2.
Synonyms: Fe-S cluster assembly protein DRE2 homologCytochrome P450 2C19
go.drugbank.com/bio_entities/BE0003536EnzymeTargetHumansOxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). … Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine
Synonyms: (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenaseQuetiapine
go.drugbank.com/drugs/DB01224ApprovedInvestigationalIt is well-tolerated and a suitable option for some patients with high sensitivity to other drugs, such as [clozapine] and [olanzapine].[A2189] … Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder.
Synonyms: 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanolMixtures: Quetialan 4 Tage Startpackung - Filmtabletten, Seroquel 4-Tage Startpackung FilmtablettenPeptidyl-prolyl cis-trans isomerase B
go.drugbank.com/bio_entities/BE0002332TargetHumansPeptidyl-prolyl cis-trans isomerase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding
Synonyms: S-cyclophilinPurine nucleoside phosphorylase
go.drugbank.com/bio_entities/BE0003172TargetPlasmodium falciparum (isolate 3D7)Also catalyzes the phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine; MTI is produced by adenosine deaminase (ADA)-mediated breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product
Synonyms: S-methyl-5'-thioinosine phosphorylaseLidocaine
go.drugbank.com/drugs/DB00281ApprovedInvestigationalVet approvedAs a result, lidocaine is also considered a class Ib anti-arrhythmic agent [L5930, L5948, F4468]. … Regardless, lidocaine is currently available as a relatively non-expensive generic medication that is written for in millions of prescriptions internationally on a yearly basis.
Synonyms: 2-(Diethylamino)-2',6'-acetoxylidide, 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamideInternational brands: LidoPain SP, L-CaineHodgkin's Lymphoma
go.drugbank.com/conditions/DBCOND0030382Drugs: Bleomycin · Chlorambucil · Cyclophosphamide · Dacarbazine · Doxorubicin · Gemcitabine +5 moreSynonyms: Hodgkin´s Lymphomas, Hodgkin´s LymphomaLeukotriene C4 synthase
go.drugbank.com/bio_entities/BE0001117TargetHumansCan also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator
Synonyms: Glutathione S-transferase LTC4Gabapentin
go.drugbank.com/drugs/DB00996ApprovedInvestigational[L8717] It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to treat neuropathic pain. … [A14097,A186179] Gabapentin has some stark advantages as compared with other anti-epileptics, such as a relatively benign adverse effect profile, wide therapeutic index, and lack of appreciable metabolism
Synonyms: 1-(Aminomethyl)cyclohexaneacetic acidMixtures: Innoprax-5, GAVINDO NCap-specific mRNA (nucleoside-2'-O-)-methyltransferase
go.drugbank.com/bio_entities/BE0001402TargetVACVDisplays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the...
Synonyms: PAP-S