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Displaying results 801 - 810 of 4626 in total
  1. Pathway

    Donepezil Action Pathway

    smpdb.ca/view/SMP0126613
    Drug action

    Donepezil is an acetylcholinesterase inhibitor also known as Adlarity, Aricept and Namzaric, that is used in the treatment of Alzheimer's Disease and dementia. It is administered orally or transdermally, sometimes in combination with mem...

    Drugs: Choline · Donepezil · Calcium · Magnesium cation · Acetylcholine · Acetic acid
    Enzymes: High affinity choline transporter 1
  2. Pathway

    Galantamine Action Pathway (new, revision)

    smpdb.ca/view/SMP0126671
    Drug action

    Galantamine is a cholinesterase inhibitor used in the treatment of Alzheimer's disease, specifically to mitigate symptoms of mild to moderate dementia. These symptoms of cognitive loss are due to acetylcholine deficiency, galantamine inh...

    Drugs: Choline · Galantamine · Calcium · Magnesium cation · Acetylcholine · Acetic acid
    Enzymes: High affinity choline transporter 1
  3. Pathway

    Minaprine Acetylcholinesterase Antidepressant Action Pathway

    smpdb.ca/view/SMP0126689
    Drug action

    Minaprine is an amino-phenylpyridazine antidepressant. It is indicated in the treatment of various depressive states. Minaprine acts on many targets in the neurons. Firstly, this drug binds as an antagonist to the serotonin type 2 recept...

    Drugs: Choline · Minaprine · Calcium · Magnesium cation · Acetylcholine · Acetic acid
    Enzymes: High affinity choline transporter 1
  4. Pathway

    Metrifonate Action Pathway

    smpdb.ca/view/SMP0126725
    Drug action

    Metrifonate is an acetylcholinesterase inhibitor, a prodrug that is non-enzymatically converted into its active form Dichlorvos. While binding to acetylcholinesterase it prevents the breakdown of acetylcholine, allowing the neurotransmit...

    Drugs: Choline · Calcium · Magnesium cation · Acetylcholine · Acetic acid · Metrifonate
    Enzymes: High affinity choline transporter 1
  5. Drug

    Lopinavir

    go.drugbank.com/drugs/DB01601
    ApprovedInvestigational

    [saquinavir], [nelfinavir]), lopinavir is a peptidomimetic molecule - it contains a hydroxyethylene scaffold that mimics the peptide linkage typically targeted by the HIV-1 protease enzyme but which itself … [A191757] Lopinavir was previously under investigation in combination with ritonavir for the treatment of COVID-19 caused by SARS-CoV-2.[L12012]

  6. Drug

    CX-051869

    go.drugbank.com/drugs/DB31656
    Approved

    CX-051869 is a COVID-19 mRNA vaccine encoding the pre-fusion stabilized Spike glycoprotein (S) of the SARS-CoV-2 Omicron variant lineage LP.8.1. It is the active ingredient of the 2025-2026 formulation of Moderna's Spikevax vaccine.

  7. Drug

    Technetium Tc-99m sestamibi

    go.drugbank.com/drugs/DB09161
    ApprovedInvestigational

    The mechanism by which sestamibi localizes to these tissues has not been established. … Following intravenous injection of the drug, Technetium Tc-99m sestamibi is taken up by the myocardium, parathyroid, and/or breast tissue.

  8. Drug

    Remdesivir

    go.drugbank.com/drugs/DB14761
    ApprovedInvestigational

    [L18438] Remdesivir is currently marketed under the trademark name VEKLURY by Gilead Sciences Inc.[L18438] Remdesivir was also approved by the European Commission on July 3, 2020. … Like other RNA viruses, SARS-CoV-2 depends on an RNA-dependent RNA polymerase (RdRp) enzyme complex for genomic replication, which can be inhibited by a class of drugs known as nucleoside analogues.

  9. Drug

    Amoxapine

    go.drugbank.com/drugs/DB00543
    Approved

    In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation. In depressed individuals, amoxapine exerts a positive effect on mood.

  10. Drug

    Proflavine

    go.drugbank.com/drugs/DB01123
    ApprovedInvestigational

    3,6-Diaminoacridine. Topical antiseptic used mainly in wound dressings.