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Displaying results 831 - 840 of 10000 in total
  1. Target

    4-aminobutyrate aminotransferase, mitochondrial

    go.drugbank.com/bio_entities/BE0000253
    TargetEnzymeHumans

    Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively (PubMed:10407778, PubMed:15528998). Can also convert delta-aminovalerate and beta-alanine...

    Synonyms: (S)-3-amino-2-methylpropionate transaminaseFunction: (S)-3-amino-2-methylpropionate
  2. Target

    Cyclopropane mycolic acid synthase MmaA2

    go.drugbank.com/bio_entities/BE0002512
    TargetMycobacterium tuberculosis

    Catalyzes the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine.

    Synonyms: S-adenosylmethionine-dependent methyltransferase
  3. Drug

    Netarsudil

    go.drugbank.com/drugs/DB13931
    ApprovedInvestigational

    solution) 0.02% for the indication of reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. … Acting as both a rho kinase inhibitor and a norepinephrine transport inhibitor, Netarsudil is a novel glaucoma medication in that it specifically targets the conventional trabecular pathway of aqueous

    Synonyms: (4-((1S)-1-(Aminomethyl)-2-(isoquinolin-6-ylamino)-2-oxoethyl)phenyl)methyl 2,4- dimethylbenzoate
  4. Target

    Putative hydrolase DDAH2

    go.drugbank.com/bio_entities/BE0000608
    TargetHumans

    Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:21493890, PubMed:37296100). In endothelial cells, induces expression of vascular endo...

    Synonyms: S-phase protein
  5. Target

    Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

    go.drugbank.com/bio_entities/BE0002256
    TargetEnzymeHumans

    Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate...

    Synonyms: SCOT-s
  6. Drug

    Tolnaftate

    go.drugbank.com/drugs/DB00525
    ApprovedVet approved

    Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm. … It is sold under several brand names, most notably Tinactin and Odor Eaters.

    Mixtures: PERMUT®, เดอมิกซ์-4Synonyms: 2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate, m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester
  7. Drug

    Magrolimab

    go.drugbank.com/drugs/DB16225
    Investigational

    Magrolimab is under investigation in clinical trial NCT02953782 (Trial of Magrolimab (Hu5f9-g4) in Combination With Cetuximab in Participants With Solid Tumors and Advanced Colorectal Cancer).

    Synonyms: Immunoglobulin g4-kappa, anti-(homo sapiens cd47 (integrin associated protein, iap, mer6, oa3)), monoclonal antibodygamma4 heavy chain (1-444) (vh (homo sapiens ighv1-3*01 (87.8%)-(ighd)-ighj4*01 (100%, )) (8.8.10) (1-117)-homo sapiens ighg4*01 (ch1 (118-2
  8. Target

    Kynurenine--oxoglutarate transaminase 1

    go.drugbank.com/bio_entities/BE0000273
    TargetEnzymeHumans

    Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:7883047)

    Synonyms: Cysteine-S-conjugate beta-lyaseFunction: cysteine-S-conjugate beta-lyase activity
  9. Target

    Hematopoietic prostaglandin D synthase

    go.drugbank.com/bio_entities/BE0001167
    TargetHumans

    Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide rang...

    Synonyms: Glutathione S-transferase
  10. Target

    Cytosolic non-specific dipeptidase

    go.drugbank.com/bio_entities/BE0018303
    EnzymeHumans

    N-[(S)-lactoyl]-L-phenylalanine is an exercise-induced metabolite that influences food intake and systemic energy balance (PubMed:25964343). … Upon physiological conditions of amino acids and lactate excess can also catalyze a reverse proteolysis reaction, generating N-[(S)-lactoyl]-L-phenylalanine and possibly other N-lactoyl-amino acids which

    Synonyms: HEL-S-13