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Displaying results 851 - 860 of 10000 in total
  1. Drug

    Filgrastim

    go.drugbank.com/drugs/DB00099
    ApprovedInvestigational

    It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the sequence for expression in _E. Coli_. … [L40714] Filgrastim was approved in the US in 1991 and there are biosimilars available with similar therapeutic indications.[A245858] Tbo-filgrastim was approved by the FDA on August 29, 2012.

    Synonyms: r-metHuG-CSFInternational brands: White-C
  2. Drug

    5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine

    go.drugbank.com/drugs/DB07142
    Experimental

    Synonyms: 5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
  3. Drug

    Etrasimod

    go.drugbank.com/drugs/DB14766
    ApprovedInvestigational

    [A261826] In fact, it has been observed that antigen-activated T cells within peripheral lymphoid organs can transiently downregulate S1P receptor levels to facilitate immune cells trafficking into the … Etrasimod is a synthetic next-generation selective Sphingosine 1-phosphate (S1P) receptor modulator that targets the S1P<sub>1,4,5</sub> with no detectable activity on S1P<sub>2</sub> and S1P<sub>3</sub

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-Ring
  4. Target

    GTP cyclohydrolase 1

    go.drugbank.com/bio_entities/BE0001814
    TargetShigella flexneri

    Synonyms: GTP-CH-I, GTP cyclohydrolase I
  5. Target

    Carbamoyl-phosphate synthase [ammonia], mitochondrial

    go.drugbank.com/bio_entities/BE0004671
    TargetEnzymeHumans

    Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell

    Synonyms: CPSase I, Carbamoyl-phosphate synthetase I
  6. Target

    Deoxyribonuclease-1

    go.drugbank.com/bio_entities/BE0012829
    TargetHumans

    Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:11241278, PubMed:2251263, PubMed:2277032). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By sim...

    Synonyms: DNase I, Deoxyribonuclease IFunction: deoxyribonuclease I activity
  7. Indication

    Accelerated Phase Chronic Myelogenous Leukemia (CML)

    go.drugbank.com/conditions/DBCOND0121922
    Drugs: Bosutinib · Dasatinib · Imatinib · Nilotinib · Ponatinib
    Synonyms: Chronic myelogenous leukemia, no ICD-O subtype, Chronic myelogenous leukemia, no ICD-O subtype (morphologic abnormality)
  8. Indication

    Classical Hodgkin's Lymphoma

    go.drugbank.com/conditions/DBCOND0113588
    Drugs: Brentuximab vedotin · Nivolumab
    Synonyms: Hodgkin lymphoma, no ICD-O subtype, Hodgkin lymphoma, no ICD-O subtype (morphologic abnormality)
  9. Drug

    Sumatriptan

    go.drugbank.com/drugs/DB00669
    ApprovedInvestigational

    [L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available in Europe in 1991 to treat migraines. … Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches.

    Mixtures: TRASS® TABLETA RECUBIERTA, TRASS® TABLETA RECUBIERTACategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, P-glycoprotein substrates
  10. Drug

    Xenon Xe-129

    go.drugbank.com/drugs/DB17386
    ApprovedInvestigational

    They undergo a process that increases nuclear polarization up to five orders of magnitude, leading to a higher MRI signal. … [Helium-3] (He-3) is the one most commonly used due to its strong signal and favorable safety profile, but its use in other applications has affected its availability.

    Synonyms: Xenon, isotope of mass 129m(8.88 d)