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Trimethoprim
go.drugbank.com/drugs/DB00440ApprovedInvestigationalVet approvedTrimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it … [L11893,L11830] It is structurally and chemically related to [pyrimethamine], another antifolate antimicrobial used in the treatment of plasmodial infections.[T707]
Mixtures: COTRIM E RATIO 480MG/5ML, EUSAPRIM E SUSPENS F ERWCategories: MATE 2 Inhibitors, MATE 2 SubstratesChlorpropamide
go.drugbank.com/drugs/DB00672ApprovedWithdrawnUp to 80% of the single oral dose of chlorpropramide is metabolized, likely in the liver; 80-90% of the dose is excreted in urine as unchanged drug and metabolites. … It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin.
Categories: Drugs Used in Diabetes, Cytochrome P-450 SubstratesSynonyms: N-(4-chlorophenylsulfonyl)-N'-propylurea, 4-chloro-N-((propylamino)carbonyl)benzenesulfonamideAbiraterone
go.drugbank.com/drugs/DB05812ApprovedInvestigationalIt is used to treat metastatic castration-resistant prostate cancer, hormone-sensitive high-risk metastatic prostate cancer. … Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsProducts: Abirateron Sandoz 1000 mg – Filmtabletten, Abirateron 1A Pharma 1000 mg – FilmtablettenBurosumab
go.drugbank.com/drugs/DB14012ApprovedInvestigationalBurosumab (KRN23) is an entirely human monoclonal IgG1 antibody that binds excess fibroblast growth factor 23 (FGF23) and has been successfully tested in clinical trials in children with X-linked hypophosphatemic … It causes impaired bone growth and development in children and adolescents and issues with bone mineralization throughout a patient’s life [L2346].
Categories: Fibroblast Growth Factor-23 Blocking AntibodiesProducts: CRYSVITA® SOLUTION FOR INJECTION 10 MG/ML, CRYSVITA 10 MG SOLUTION FOR INJECTIONUrea C-13
go.drugbank.com/drugs/DB09510ApprovedInvestigationalBoth forms can be used within the Urea Breath Test, however some may prefer 13C as it is non-radioactive compared to 14C, which may be preferable in pregnant women and children. … If gastric urease from H. pylori is present, urea is split to form CO2 and NH3 at the interface between the gastric epithelium and lumen and 13CO2 is absorbed into the blood and exhaled in the breath.
Products: Diabact UBT 50 mg Tabletten, Tablet 100 mgEmpagliflozin
go.drugbank.com/drugs/DB09038ApprovedInvestigational[A203453] It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 diabetes mellitus. … Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney.
Mixtures: GLYXAMBI® 10 MG/ 5 MG, GLYXAMBI® 25 MG/ 5 MGCategories: Drugs Used in Diabetes, Sodium-Glucose Transporter 2 InhibitorsNaloxone
go.drugbank.com/drugs/DB01183ApprovedInvestigationalVet approved[A234594] More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, causing the rapid removal of any other drugs bound to these receptors. … Notably, if injected into a person not currently using opioid medications, there would be no noticeable effects at all.
Mixtures: Targin 20 mg/10 mg Retardtabletten, Oxylanox 20 mg/10 mg-RetardtablettenCategories: Heterocyclic Compounds with 4 or More Rings, Cytochrome P-450 SubstratesLactic acid
go.drugbank.com/drugs/DB04398ApprovedInvestigationalVet approved(From Stedman, 26th ed) Sodium lactate is the sodium salt of lactic acid, and has a mild saline taste. … Lactic acid was one of active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020.[L14120]
Mixtures: SOLUCION DP PISA 2.5%(MODIFICADA EN MAGNESIO Y LACTATO), (HARTMANN`S SOLUTION ) WITH 5% GLUCOSE IN 1000 ML PLASTIC CONTAINERSynonyms: 2-Hydroxypropanoic acid, 2-Hydroxypropionic acidMeropenem
go.drugbank.com/drugs/DB00760ApprovedInvestigationalIt is active against Gram-positive and Gram-negative bacteria. … In August 2017, a combination antibacterial therapy under the market name vabomere was approved for treatment of adult patients with complicated urinary tract infections (cUTI).
Categories: Heterocyclic Compounds, 2-RingSynonyms: (4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acidBeta carotene
go.drugbank.com/drugs/DB06755ApprovedNutraceuticalIt is an antioxidant that can be found in yellow, orange and green leafy vegetables and fruits.[T158] Under the FDA, beta-carotene is considered as a generally recognized as safe substance (GRAS). … [T162] It is the most abundant form of carotenoid and it is a precursor of the vitamin A. Beta-carotene is composed of two retinyl groups.
Mixtures: ACECAP 20/200/200 MG YUMUŞAK KAPSÜL, 30 ADET, Folika-MGProducts: CAROVIT 20 MG YUMUSAK KAPSUL, 100 ADET, CAROVIT 20 MG YUMUSAK KAPSUL, 30 ADET