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Displaying results 881 - 890 of 10000 in total
  1. Drug

    Azithromycin

    go.drugbank.com/drugs/DB00207
    ApprovedInvestigational

    In March 2020, a small study was funded by the French government to investigate the treatment of COVID-19 with a combination of azithromycin and the anti-malaria drug [hydroxychloroquine]. … It is structurally related to erythromycin [A174169].

    Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: Zithromax Cap 250mg, ZITHROMAX TR-SAFT K B 25KG
  2. Drug

    Mepivacaine

    go.drugbank.com/drugs/DB00961
    ApprovedInvestigationalVet approved

    A local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. … Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)

    Mixtures: Carbocaine 2% With Neo-cobefrin, Carbocaine 2% With Neo-cobefrinCategories: Heterocyclic Compounds, 1-Ring
  3. Indication

    Cutaneous Squamous Cell Carcinoma (CSCC)

    go.drugbank.com/conditions/DBCOND0168836
    Drugs: Cemiplimab
    Synonyms: Squamous cell carcinoma, no ICD-O subtype, Squamous cell carcinoma, no International Classification of Diseases for Oncology subtype
  4. Drug

    5-[(3R)-3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine

    go.drugbank.com/drugs/DB07141
    Experimental

    Synonyms: 5-[(3R)-3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
  5. Target

    DNA-3-methyladenine glycosylase 1

    go.drugbank.com/bio_entities/BE0001657
    TargetEscherichia coli (strain K12)

    Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions.

    Synonyms: TAG I, DNA-3-methyladenine glycosidase I
  6. Drug

    Perindopril

    go.drugbank.com/drugs/DB00790
    ApprovedInvestigational

    Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). … It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration.

    Mixtures: COVERATRIX 5 MG/1.25 MG/10 MG COMPRIMIDOS RECUBIERTOS CON PELÍCULA, COVERATRIX 10 MG / 2.5 MG / 5 MG COMPRIMIDOS RECUBIERTOS CON PELÍCULACategories: Heterocyclic Compounds, 2-Ring, Agents Acting on the Renin-Angiotensin System
  7. Drug

    Novobiocin

    go.drugbank.com/drugs/DB01051
    ApprovedInvestigationalVet approvedWithdrawn

    Novobiocin is an antibiotic compound derived from _Streptomyces niveus_. It has a chemical structure similar to coumarin. … Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity.

    Synonyms: N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-β-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl}-4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamideCategories: Coumarins, Heterocyclic Compounds, 1-Ring
  8. Indication

    XLH

    go.drugbank.com/conditions/DBCOND0125908
    Drugs: Burosumab
    Synonyms: HPDR I - Hypophosphatemic vitamin D-resistant rickets, HPDR I - Hypophosphataemic vitamin D-resistant rickets
  9. Indication

    Anorexia

    go.drugbank.com/conditions/DBCOND0004522
    Drugs: Dronabinol · Hemicellulase · Itopride · Megestrol acetate
    Synonyms: No appetite
  10. Target

    Insulin-like growth factor 1 receptor

    go.drugbank.com/bio_entities/BE0000858
    TargetHumans

    JNK kinases can also be activated by the IGF1R. … Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins.

    Synonyms: IGF-I receptor, Insulin-like growth factor I receptor